RARRES2 Human, HEK
HEK293.
Greater than 90.0% as determined by SDS-PAGE.
Description
RARRES2 produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain (21-157 a.a.) and fused to a 6 aa His Tag at C-terminus containing a total of 143 amino acids and having a molecular mass of 16.6kDa.
RARRES2 shows multiple bands between 13.5-18kDa on SDS-PAGE, reducing conditions and purified by proprietary chromatographic techniques.
Product Specs
This section provides a concise summary of RARRES2, a chemotactic protein. It should briefly describe its function, tissue expression, and relevant biological activities, specifically tailored for the Human, HEK context.
This part details the characteristics of the produced RARRES2 Human, HEK. It should specify the expression system, molecular weight, tag information, and observed SDS-PAGE profile.
Describe the visual appearance of the RARRES2 Human, HEK solution, typically a clear and colorless solution.
This section outlines the composition of the buffer or solution in which the RARRES2 Human, HEK is provided. It typically includes the protein concentration, buffer components, and pH.
Provide instructions on how to properly store the RARRES2 Human, HEK product to maintain its stability and activity. Include details about recommended storage temperature, duration, and any precautions, such as avoiding repeated freeze-thaw cycles.
Specify the purity level of the RARRES2 Human, HEK product, determined by SDS-PAGE analysis. Express it as a percentage, typically greater than 90%.
HEK293.
ELTEAQRRGL QVALEEFHKH PPVQWAFQET SVESAVDTPF PAGIFVRLEF KLQQTSCRKR DWKKPECKVR PNGRKRKCLA CIKLGSEDKV LGRLVHCPIE TQVLREAEEH QETQCLRVQR AGEDPHSFYF PGQFAFSHHH HHH.
Product Science Overview
RARRES2 is a protein-coding gene that is upregulated by the synthetic retinoid tazarotene. The protein encoded by this gene initiates chemotaxis via the ChemR23 G protein-coupled seven-transmembrane domain ligand . It is expressed in a wide variety of tissues and has several roles, including acting as an adipokine and an antimicrobial protein with activity against bacteria and fungi .
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Adipogenesis and Metabolism: RARRES2 regulates adipogenesis, metabolism, and inflammation through activation of the chemokine-like receptor 1 (CMKLR1). It also acts as a ligand for CMKLR2 and can bind to C-C chemokine receptor-like 2 (CCRL2) with a lower affinity . The protein positively regulates adipocyte differentiation and modulates the expression of adipocyte genes involved in lipid and glucose metabolism .
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Inflammation: RARRES2 acts as a pro-inflammatory adipokine, causing an increase in the secretion of pro-inflammatory and prodiabetic adipokines. This further impairs adipose tissue metabolic function and has negative systemic effects, including impaired insulin sensitivity, altered glucose and lipid metabolism, and decreased vascular function in other tissues .
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Antimicrobial Activity: The protein has antimicrobial properties, providing activity against bacteria and fungi .
RARRES2 is associated with several diseases, including Schnitzler Syndrome and Psoriasis . It is also involved in pathways related to the response to elevated platelet cytosolic Ca2+ . The protein’s role in inflammation and metabolism makes it a potential target for therapeutic interventions in metabolic disorders and inflammatory diseases.
The RARRES2 gene has been studied in various species, including baboons and chimpanzees. The gene’s evolution fits the hypothesis of purifying selection, and its expression profiles are similar in these species . RARRES2 transcripts are present in multiple tissues, including the liver, lung, adipose tissue, ovary, pancreas, heart, hypothalamus, and pituitary .
