RARRES2 Human, His
Retinoic Acid Receptor Responder 2 Human Recombinant, His Tag
Cat. No.
BT15114
Source
Escherichia Coli.
Synonyms
Chemerin, TIG2, Tazarotene-induced gene 2 protein, Retinoic acid receptor responder protein 2, RAR-responsive protein TIG2, RARRES2, HP10433.
Appearance
Sterile Filtered colorless solution.
Purity
Greater than 85.0% as determined by SDS-PAGE.
Usage
THE BioTek's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
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Description
RARRES2 Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 158 amino acids (21-157a.a) and having a total molecular mass of 18 kDa.
RARRES2 is fused to a 21 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
RARRES2 is fused to a 21 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Product Specs
Introduction
The protein RARRES2, also known as chemerin, plays a crucial role in immune response and metabolism. It functions as a chemotactic protein, attracting specific immune cells like immature dendritic cells and macrophages to sites of inflammation. This process is initiated when RARRES2 binds to its receptor, ChemR23, a G protein-coupled receptor found on the surface of these immune cells. RARRES2 is also recognized as an adipokine, a signaling molecule produced by adipose tissue, and has been linked to adipocyte differentiation and metabolic regulation. Interestingly, the receptor for RARRES2, ChemR23, can also interact with certain viruses, including SIV and some HIV-1 strains.
Description
Recombinant RARRES2 Human protein, expressed in E. coli, is a single polypeptide chain. This non-glycosylated protein consists of 158 amino acids (21-157a.a), with a 21 amino acid His-tag attached at the N-terminus. With a molecular weight of 18 kDa, it is purified using proprietary chromatographic techniques.
Physical Appearance
Clear, colorless solution, sterilized by filtration.
Formulation
The RARRES2 protein is supplied in a solution at a concentration of 1mg/ml. The solution is buffered with 20mM Tris-HCl at pH 8.0 and contains 0.4M Urea and 10% glycerol.
Stability
For short-term storage (up to 4 weeks), the protein should be stored at 4°C. For long-term storage, it is recommended to store the protein at -20°C. To prevent protein degradation from repeated freezing and thawing, adding a carrier protein such as HSA or BSA (0.1%) is advised.
Purity
The purity of the RARRES2 protein is determined to be greater than 85% using SDS-PAGE analysis.
Synonyms
Chemerin, TIG2, Tazarotene-induced gene 2 protein, Retinoic acid receptor responder protein 2, RAR-responsive protein TIG2, RARRES2, HP10433.
Source
Escherichia Coli.
Amino Acid Sequence
MGSSHHHHHH SSGLVPRGSH MELTEAQRRG LQVALEEFHK HPPVQWAFQE TSVESAVDTP FPAGIFVRLE FKLQQTSCRK RDWKKPECKV RPNGRKRKCL ACIKLGSEDK VLGRLVHCPI ETQVLREAEE HQETQCLRVQ RAGEDPHSFY FPGQFAFS.
Product Science Overview
Gene and Protein Structure
The RARRES2 gene encodes a secreted chemotactic protein that initiates chemotaxis via the ChemR23 G protein-coupled seven-transmembrane domain ligand . The human recombinant version of this protein, tagged with a His (histidine) tag, is produced in E. coli and consists of a single, non-glycosylated polypeptide chain containing 158 amino acids (21-157 a.a.) with a total molecular mass of approximately 18 kDa .
Expression and Regulation
Functional Roles
RARRES2 plays a significant role in:
- Adipogenesis and Metabolism: It regulates adipocyte differentiation and modulates the expression of adipocyte genes involved in lipid and glucose metabolism .
- Inflammation: It acts as a pro-inflammatory adipokine, causing an increase in the secretion of pro-inflammatory and pro-diabetic adipokines . This further impairs adipose tissue metabolic function and has negative systemic effects, including impaired insulin sensitivity, altered glucose and lipid metabolism, and decreased vascular function in other tissues .
Clinical Significance
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