Rantes Human, His
Description
The Rantes His is purified by proprietary chromatographic techniques.
Product Specs
Product Science Overview
RANTES, also known as CCL5 (C-C motif chemokine ligand 5), is a member of the chemokine family. Chemokines are small cytokines or signaling proteins secreted by cells, and they play a crucial role in immune responses by directing the migration of immune cells to sites of inflammation or injury . RANTES is classified as a beta-chemokine due to its structure and function .
RANTES is an 8 kDa protein that is chemotactic for T cells, eosinophils, and basophils . It plays a significant role in recruiting leukocytes to inflammatory sites, thereby contributing to the body’s immune response . The recombinant form of RANTES, tagged with a His (histidine) tag, is produced using recombinant DNA technology, which allows for the expression of the protein in host cells such as E. coli or HEK293 cells .
RANTES plays a pivotal role in the inflammatory immune response. It attracts and activates leukocytes, including T cells, eosinophils, and basophils, to sites of infection or injury . This chemokine is involved in various physiological and pathological processes, including immune surveillance, wound healing, and the development of inflammatory diseases .
RANTES exerts its effects by binding to specific receptors on the surface of target cells. The primary receptors for RANTES are CCR1, CCR3, and CCR5, which are G protein-coupled receptors . Upon binding to these receptors, RANTES activates intracellular signaling pathways that lead to the migration and activation of immune cells .
The expression and activity of RANTES are tightly regulated at multiple levels. Transcriptional regulation is influenced by various cytokines and transcription factors that respond to inflammatory signals . Post-translational modifications, such as glycosylation, also play a role in modulating the stability and activity of RANTES .
