RAB6A Human
Description
RAB6A Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 262 amino acids (1-208) and having a molecular mass of 26.1kDa.
RAB6A is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Product Specs
MGSSHHHHHH SSGLVPRGSH MGSHMSTGGD FGNPLRKFKL VFLGEQSVGK TSLITRFMYD SFDNTYQATI GIDFLSKTMY LEDRTIRLQL WDTAGQERFR SLIPSYIRDS AAAVVVYDIT NVNSFQQTTK WIDDVRTERG SDVIIMLVGN KTDLADKRQV SIEEGERKAK ELNVMFIETS AKAGYNVKQL FRRVAAALPG MESTQDRSRE DMIDIKLEKP QEQPVSEGGC SC.
Product Science Overview
RAB6A is a member of the RAS oncogene family, which belongs to the small GTPase superfamily. This protein is encoded by the RAB6A gene and is involved in various cellular processes, particularly in the regulation of intracellular trafficking.
The RAB6A gene is located on chromosome 11 and encodes a protein that is part of the Rab family of small GTPases. These proteins are key regulators of vesicular trafficking pathways. The RAB6A protein is ubiquitously expressed and has several isoforms due to alternative splicing events. The primary isoforms include RAB6A and RAB6A’, which are expressed in various tissues, and RAB6B, which is brain-specific .
RAB6A plays a crucial role in the regulation of retrograde transport from the Golgi apparatus to the endoplasmic reticulum (ER). It is involved in both retrograde (from early endosomes and Golgi to the ER) and anterograde (from the Golgi to the plasma membrane) trafficking. This protein interacts with various effectors to regulate the targeting and fusion of transport carriers to acceptor compartments .
One of the key functions of RAB6A is its role in the assembly of human cytomegalovirus (HCMV). It interacts with the cellular protein Bicaudal D1, which in turn interacts with the HCMV virion tegument protein, pp150 .
Recombinant RAB6A proteins are widely used in research to study the protein’s function and its role in various cellular processes. These recombinant proteins are typically expressed in systems such as E. coli and purified for use in various assays. They are used in blocking experiments, immunohistochemistry (IHC), immunocytochemistry (ICC), and Western blotting (WB) to study protein interactions and functions .
