RAB2A Human

RAB2A, a member of the RAS oncogene family, is a small GTPase that plays a crucial role in intracellular membrane trafficking. This protein is involved in the formation of transport vesicles and their fusion with target membranes, which is essential for maintaining organelle identity and morphology .

The RAB2A gene is located on chromosome 8 and encodes a protein that is part of the Rab family of small GTPases. These proteins are known for their highly conserved domains involved in GTP binding and hydrolysis . The RAB2A protein is a resident of pre-Golgi intermediates and is required for protein transport from the endoplasmic reticulum (ER) to the Golgi complex .

RAB2A cycles between an active GTP-bound state and an inactive GDP-bound state. In its active state, RAB2A drives the transport of vesicular carriers from donor organelles to acceptor organelles, regulating membrane traffic . This regulation is crucial for the compacted morphology of the Golgi apparatus and efficient autophagic flux .

Mutations or dysregulation of RAB2A have been associated with various diseases, including lipoblastoma and Sezary’s disease . The protein’s role in vesicular trafficking and autophagy makes it a potential target for therapeutic interventions in these conditions.

Recombinant human RAB2A is often used in research to study its function and interactions. The protein is typically provided in a solution containing Tris-HCl buffer, DTT, glycerol, and NaCl . This recombinant form allows for detailed biochemical and structural studies, contributing to our understanding of its role in cellular processes.