Procalcitonin Human
Procalcitonin Human Recombinant
Cat. No.
BT17831
Source
Escherichia Coli.
Synonyms
Procalcitonin, PCT.
Appearance
Sterile Filtered White lyophilized (freeze-dried) powder.
Purity
Greater than 95.0% as determined by SDS-PAGE.
Usage
Prospec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
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Description
Procalcitonin Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 116 amino acids and having a molecular mass of 12.8 kDa.
The Procalcitonin is purified by standard chromatographic techniques.
The Procalcitonin is purified by standard chromatographic techniques.
Product Specs
Introduction
Procalcitonin, a peptide hormone primarily synthesized by the thyroid gland's C cells and specific endocrine cells within the lungs, undergoes cleavage into three distinct fragments under typical conditions: an N-terminal residue, calcitonin, and katacalcin. However, in response to bacterial infections, trauma, or shock, levels of uncleaved procalcitonin exhibit a substantial increase.
Description
Produced in E. coli, Recombinant Human Procalcitonin is a single, non-glycosylated polypeptide chain comprising 116 amino acids, resulting in a molecular weight of 12.8 kDa. The purification of Procalcitonin is achieved through standard chromatographic techniques.
Physical Appearance
Sterile Filtered White lyophilized powder.
Formulation
Lyophilized from a 10mM sodium phosphate solution at a pH of 7.5.
Solubility
For reconstitution of the lyophilized procalcitonin, it is advised to use sterile 18MΩ-cm H2O at a concentration of 100 µg/ml. Further dilutions can be made using other aqueous solutions.
Stability
Lyophilized procalcitonin demonstrates stability at room temperature for a duration of 3 weeks; however, it is recommended to store it desiccated below -18°C. Following reconstitution, procalcitonin should be stored at 4°C for a period of 2-7 days. For long-term storage, it is advisable to freeze it below -18°C. The addition of a carrier protein (0.1% HSA or BSA) is recommended for extended storage. Repeated freeze-thaw cycles should be avoided.
Purity
SDS-PAGE analysis indicates a purity greater than 95.0%.
Synonyms
Procalcitonin, PCT.
Source
Escherichia Coli.
Amino Acid Sequence
APFRSALESS PADPATLSED EARLLLAALV QDYVQMKASE LEQEQEREGS SLDSPRSKRC GNLSTCMLGT YTQDFNKFHT FPQTAIGVGA PGKKRDMSSD LERDHRPHVS MPQNAN.
Product Science Overview
Structure and Production
Procalcitonin is encoded by the CALCA gene and consists of 116 amino acids. The recombinant form of human procalcitonin is typically produced in Escherichia coli (E. coli) and is a single, non-glycosylated polypeptide chain . The molecular weight of recombinant human procalcitonin is approximately 12.8 kDa .
Function and Clinical Significance
Applications
Recombinant human procalcitonin is used in various research applications, including:
- Biomarker Studies: To study its role as a biomarker in bacterial infections and sepsis.
- Protein Interaction Studies: To understand its interactions with other proteins and molecules.
- Drug Development: To develop new therapeutic agents targeting procalcitonin pathways.
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