PLGF2 Human, CHO

Placental Growth Factor (PlGF) is a member of the vascular endothelial growth factor (VEGF) family, which plays a crucial role in angiogenesis and vasculogenesis. PlGF has four isoforms (PlGF-1 to PlGF-4), with PlGF-2 being one of the most biologically active forms. Recombinant human PlGF-2 (rhPlGF-2) is produced using Chinese Hamster Ovary (CHO) cells, which are commonly used in biotechnology for the production of therapeutic proteins.

PlGF-2 is primarily involved in the formation of new blood vessels (angiogenesis) and the growth of existing ones (arteriogenesis) under pathological conditions. It exerts its effects by binding to the VEGF receptor-1 (VEGFR-1), which is expressed on various cell types, including endothelial cells, monocytes, and macrophages .

The therapeutic potential of rhPlGF-2 has been explored in various preclinical and clinical studies. One of the key areas of interest is its application in cardiovascular diseases, particularly in the context of myocardial infarction (heart attack) and ischemic cardiomyopathy. Studies have shown that rhPlGF-2 can induce angiogenesis and improve cardiac function in animal models of myocardial infarction .

In a preclinical study involving pigs with induced myocardial infarction, continuous intravenous infusion of rhPlGF-2 was found to be safe and associated with favorable post-infarct remodeling. However, the study did not show significant improvements in global cardiac function or neovascularization . Another study in mice with advanced atherosclerosis and chronic ischemic cardiomyopathy demonstrated that rhPlGF-2 improved contractile function and increased capillary and arteriolar density in ischemic myocardium without aggravating atherosclerosis .

Despite the promising results in preclinical studies, the translation of rhPlGF-2 therapy to clinical practice faces several challenges. One of the main challenges is the need for well-designed clinical trials in representative large animal models to ensure the safety and efficacy of the therapy. Additionally, understanding the molecular mechanisms underlying the effects of rhPlGF-2 and optimizing its delivery methods are crucial for its successful clinical application .