PLGF1 Human, Sf9

Placental Growth Factor-1 (PLGF-1) is a member of the vascular endothelial growth factor (VEGF) family, which plays a crucial role in angiogenesis and vasculogenesis. This protein is particularly significant in the context of pregnancy, where it contributes to the development of the placenta and the establishment of a healthy blood supply to the fetus.

PLGF-1 is a glycosylated polypeptide chain that forms a homodimer. The human recombinant version of PLGF-1 produced in Sf9 insect cells consists of two polypeptide chains, each containing 131 amino acids, resulting in a total molecular mass of approximately 34 kDa . The recombinant protein is purified using proprietary chromatographic techniques to ensure high purity and activity .

PLGF-1 is primarily involved in the regulation of angiogenesis, the process by which new blood vessels form from pre-existing vessels. This is essential for the proper development of the placenta during pregnancy. PLGF-1 binds to the VEGF receptor-1 (VEGFR-1), promoting endothelial cell proliferation, migration, and survival. It also enhances the permeability of blood vessels, facilitating the exchange of nutrients and waste products between the mother and the fetus.

PLGF-1 has been extensively studied for its role in various pathological conditions, particularly in pregnancy-related disorders such as pre-eclampsia. Pre-eclampsia is characterized by high blood pressure and proteinuria, and it can lead to serious complications for both the mother and the baby if not properly managed. PLGF-based diagnostic tests are used to help diagnose and monitor pre-eclampsia, providing valuable information for clinical decision-making .

The recombinant form of PLGF-1 is widely used in research to study its biological functions and potential therapeutic applications. It is also used in the development of diagnostic assays for pre-eclampsia and other conditions associated with abnormal angiogenesis. The availability of high-quality recombinant PLGF-1 allows researchers to conduct detailed studies on its mechanisms of action and interactions with other proteins.