NT5E (CD73) Human
Description
Product Specs
Product Science Overview
CD73 is a 70 kDa enzyme that exists as a dimer of two identical subunits . It is anchored to the plasma membrane via a GPI linkage . The primary function of CD73 is to catalyze the conversion of adenosine monophosphate (AMP) to adenosine . This reaction is significant because adenosine acts as an important signaling molecule involved in various biological processes, including inflammation, immune response, and tissue protection .
CD73 is expressed on the surface of various cell types, including T and B lymphocytes, endothelial cells, epithelial cells, and mesenchymal stem cells . It is also found in multiple tissues such as the endometrium, synovial joint cartilage, and smooth muscle tissue . The enzyme’s expression is regulated by several transcription factors, including AP-2, SMAD proteins, and SP-1 .
CD73 plays a pivotal role in maintaining immune system homeostasis by mediating the hydrolysis of ATP and ADP to adenosine, which has anti-inflammatory properties . This enzyme is also involved in the regulation of leukocyte adhesion and migration, as well as the modulation of T cell activation . Additionally, CD73 has been implicated in various pathological conditions, including cancer, where it contributes to immune suppression within the tumor microenvironment .
Due to its role in immune regulation and tissue protection, CD73 is a potential therapeutic target for various diseases. In cancer, for instance, inhibiting CD73 activity can enhance anti-tumor immune responses . Moreover, CD73’s involvement in cardiac, neural, and renal functions highlights its significance in broader physiological contexts .
