Norovirus Group-I Paired Antibody
Description
Please note that when ordering for example: 100µg antibody we ship 50µg from each of the antibodies (100µg in total).
Product Specs
Important: When placing an order, for example, for 100µg of antibody, you will receive 50µg of each antibody type (totaling 100µg).
* Norovirus Group I conjugating antibody is provided in a solution of 1xPBS with a pH of 7.4.
This antibody pair is designed for use in lateral flow immunoassays.
Purified monoclonal IgG by protein A chromatography.
Product Science Overview
Noroviruses are a group of viruses that cause gastroenteritis, an illness characterized by symptoms such as abdominal pain, diarrhea, vomiting, and nausea. These viruses are highly contagious and can spread through contaminated food, water, surfaces, or direct person-to-person contact. Noroviruses are categorized into two main groups: Group I and Group II. Group I noroviruses are one of the primary causes of viral gastroenteritis worldwide, leading to significant morbidity and mortality, especially among vulnerable populations such as the very young, elderly, and immunocompromised individuals .
Mouse Anti Norovirus Group-I Paired Antibodies are monoclonal antibodies specifically developed to detect Norovirus Group-I antigens. These antibodies are used in various diagnostic applications, particularly in rapid stool tests to identify norovirus infections.
Characteristics and Development
- Type: Monoclonal antibodies derived from mice.
- Target: These antibodies target the viral nuclear protein of Norovirus Group-I.
- Function: The paired antibodies consist of a capture antibody and a conjugating antibody. The capture antibody is used as a coating antibody, while the conjugating antibody binds to colloid gold, facilitating the detection of the viral antigen .
Purification and Formulation
- Purification Method: The antibodies are purified using protein A chromatography, ensuring a purity greater than 95%.
- Formulation: The antibodies are provided in a sterile filtered clear colorless solution, typically in 1xPBS (phosphate-buffered saline) at pH 7.4 .
Storage and Stability
- Short-term Storage: The antibodies are stable at 4°C for up to one week.
- Long-term Storage: For extended storage, it is recommended to keep the antibodies below -18°C. Adding a carrier protein such as 0.1% HSA (human serum albumin) or BSA (bovine serum albumin) can enhance stability. It is crucial to avoid freeze-thaw cycles to maintain antibody integrity .
Mouse Anti Norovirus Group-I Paired Antibodies are primarily used in lateral flow immunoassays, a type of rapid diagnostic test. These assays are valuable in clinical settings for the quick and accurate detection of norovirus infections, aiding in timely diagnosis and management of gastroenteritis outbreaks .
