MIG Human, His
Description
MIG is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Product Specs
Product Science Overview
Monokine Induced by Gamma Interferon (MIG), also known as Chemokine (C-X-C motif) ligand 9 (CXCL9), is a small cytokine belonging to the CXC chemokine family. It plays a crucial role in immune response and inflammation by affecting the growth, movement, or activation state of cells involved in these processes .
CXCL9 is a member of the ELR-negative CXC chemokine subfamily, which lacks the Glu-Leu-Arg (ELR) motif. It is induced by interferon-gamma (IFN-γ) and is primarily expressed by macrophages, endothelial cells, and fibroblasts . The recombinant form of CXCL9, often tagged with a His tag for purification purposes, is produced in various expression systems such as E. coli or HEK293 cells .
CXCL9 functions as one of the three ligands for the chemokine receptor CXCR3, a G protein-coupled receptor predominantly found on T cells. By binding to CXCR3, CXCL9 can recruit CXCR3+ cells, including effector T cells, regulatory T cells (Tregs), and CD8+ cytotoxic T cells . This recruitment is essential for the immune response, as it helps direct these cells to sites of inflammation or infection.
CXCL9 is involved in various immune and inflammatory responses. It has been observed that tumor endothelial cells secrete high levels of CXCL9, which may facilitate the migration of tumor cells and contribute to metastasis . Additionally, CXCL9 plays a role in autoimmune diseases and chronic inflammatory conditions by recruiting immune cells to the affected tissues .
