IL 5 Mouse

IL-5 was originally identified as a T-cell-derived cytokine that triggers activated B cells to differentiate into antibody-secreting plasma cells . It was also recognized as a major maturation and differentiation factor for eosinophils in both mice and humans . Structurally, IL-5 is a glycosylated, disulfide-linked homodimer composed of two 113 amino acid chains .

IL-5 plays a pivotal role in the immune system by regulating the expression of genes involved in cell proliferation, survival, and maturation . It is crucial for the development and activation of eosinophils, which are key players in allergic responses and asthma . Additionally, IL-5 influences B-cell growth and differentiation, contributing to the production of antibodies .

Recombinant IL-5 (Mouse) is produced using E. coli expression systems and is available as a sterile, lyophilized powder . It is typically reconstituted with sterile water and used in various research applications to study its effects on eosinophils and B cells . The recombinant protein is highly pure, with endotoxin levels measured by LAL analysis being less than 0.01 ng/µg .

The understanding of IL-5’s role in eosinophil-mediated inflammation has led to the development of therapeutic options targeting IL-5 or its receptor . Monoclonal antibodies against IL-5, such as mepolizumab, have shown promise in reducing excessive eosinophilia and are currently in clinical trials .