IL5RA Mouse

Interleukin-5 receptor alpha (IL-5Rα) is a critical component in the immune system, particularly in the regulation and function of eosinophils. This receptor is a part of the cytokine receptor family and plays a significant role in various immune responses, including allergic reactions and asthma.

The IL-5 receptor is a heterodimer composed of an alpha (α) and a beta (βc) subunit. The alpha subunit is specific to IL-5, while the beta subunit is shared with receptors for interleukin-3 (IL-3) and granulocyte-macrophage colony-stimulating factor (GM-CSF) . The glycosylation of the Asn 196 residue of the Rα subunit is essential for the binding of IL-5 .

IL-5Rα is primarily involved in the growth, differentiation, and activation of eosinophils. Eosinophils are white blood cells that play a crucial role in the body’s immune response, particularly in combating parasitic infections and contributing to allergic reactions . The receptor’s activation by IL-5 triggers a cascade of intracellular events that lead to the proliferation and survival of eosinophils .

Given its pivotal role in eosinophil regulation, IL-5Rα is a therapeutic target for treating hypereosinophilic diseases, including allergic inflammations and asthma . Therapeutic agents targeting IL-5Rα can help modulate the immune response and alleviate symptoms associated with these conditions.

Recombinant IL-5Rα, particularly from mouse models, is extensively used in research to study its function and therapeutic potential. These recombinant proteins are produced using various expression systems and are crucial for in vitro and in vivo studies . They help in understanding the receptor’s role in immune responses and in developing targeted therapies.