Interleukin 2 Antibody

Interleukin-2 (IL-2) is a cytokine that plays a crucial role in the immune response. It is primarily produced by activated CD4+ T cells and is essential for the proliferation and differentiation of T cells. The rat anti-mouse IL-2 antibody is a monoclonal antibody used in research to study the function and regulation of IL-2 in mouse models.

IL-2 is a key regulator of the immune system. It induces cell cycle progression in resting cells and allows for the clonal expansion of activated T cells . IL-2 is also involved in the activation and proliferation of natural killer (NK) cells, which are critical for the body’s defense against infections and tumors .

The rat anti-mouse IL-2 antibody is a monoclonal antibody that specifically binds to mouse IL-2. This antibody is used in various immunological assays to detect and quantify IL-2 levels in mouse samples. It is also used in functional studies to block or neutralize IL-2 activity, allowing researchers to investigate the role of IL-2 in immune responses.

1. Immunoassays: The rat anti-mouse IL-2 antibody is commonly used in enzyme-linked immunosorbent assays (ELISA) and flow cytometry to measure IL-2 levels in biological samples.
2. Functional Studies: By blocking IL-2 activity, researchers can study the effects of IL-2 on T cell proliferation, differentiation, and cytokine production.
3. In Vivo Studies: The antibody is used in animal models to investigate the role of IL-2 in various diseases, including autoimmune disorders, infections, and cancer.

IL-2 has been explored as a therapeutic agent in cancer immunotherapy due to its ability to stimulate the immune system. However, its clinical use is limited by its short half-life and the activation of regulatory T cells (Tregs), which can suppress the immune response . Researchers are working on engineering IL-2 variants and developing combination therapies to enhance its efficacy and reduce side effects.