IFN A Neut Antibody
THE BioTek's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
Description
Product Specs
Product Science Overview
Interferons (IFNs) are a group of signaling proteins made and released by host cells in response to the presence of pathogens, such as viruses, bacteria, parasites, or tumor cells. They play a crucial role in the immune response by interfering with viral replication within host cells, activating immune cells, and increasing host defenses. Among the different types of interferons, Interferon-alpha (IFN-α) is a type I interferon that has potent antiviral, antiproliferative, and immunomodulatory activities .
IFN-α is produced by leukocytes and is involved in the innate immune response to viral infections. It binds to specific receptors on the surface of cells, initiating a signaling cascade that leads to the expression of various antiviral proteins. There are multiple subtypes of IFN-α, each with slightly different properties and functions .
Neutralizing antibodies are a specific type of antibody that can neutralize the biological effects of their target antigen. In the context of IFN-α, neutralizing antibodies can bind to IFN-α and prevent it from interacting with its receptor, thereby inhibiting its biological activity. These antibodies are valuable tools for studying the function of IFN-α and for developing therapeutic strategies to modulate its activity in various diseases .
Mouse anti-human IFN-α antibodies are monoclonal antibodies produced by immunizing mice with human IFN-α. These antibodies are then harvested and purified for use in research and therapeutic applications. One such example is the clone MMHA-2, which has high binding affinity to human IFN-α and is suitable for use in neutralization assays, ELISA, and Western blotting .
- Research: Neutralizing antibodies against IFN-α are used in research to study the role of IFN-α in various biological processes, including viral infections, cancer, and autoimmune diseases. They help in understanding the mechanisms of IFN-α action and in identifying potential therapeutic targets .
- Therapeutics: These antibodies have potential therapeutic applications in conditions where IFN-α is dysregulated, such as in certain autoimmune diseases and chronic viral infections. By neutralizing IFN-α, these antibodies can help modulate the immune response and alleviate disease symptoms .
