IL 7 Rat
Description
The IL 7 is purified by proprietary chromatographic techniques.
Product Specs
Product Science Overview
Interleukin-7 (IL-7) is a crucial cytokine involved in the regulation of immune responses. It plays a significant role in the development and homeostasis of T cells, B cells, and natural killer (NK) cells. Recombinant IL-7, including rat recombinant IL-7, is widely used in research to study its effects on various immune cells and its potential therapeutic applications.
IL-7 was first discovered in the late 20th century for its growth-promoting effects on B cell progenitors . It is a 25-kDa soluble globular protein produced by various cells, including stromal cells in the bone marrow, thymus, keratinocytes, and enterocytes . The IL-7 receptor (IL-7R) is a heterodimeric complex consisting of the α-chain (CD127) and the common cytokine receptor γ-chain (CD132), which is shared with receptors for other cytokines such as IL-2, IL-4, IL-9, IL-15, and IL-21 .
IL-7 is essential for the development and survival of T cells in the thymus and the maintenance of peripheral T cells . It also plays a role in B cell maturation and the proliferation and differentiation of memory and naive T cells . IL-7 exerts its biological effects through the activation of the IL-7R, which triggers downstream signaling pathways, including the Janus kinase (JAK)-signal transducer and activator of transcription (STAT) pathway and the phosphatidylinositol 3-kinase (PI3K)-protein kinase B (AKT) pathway .
Recombinant IL-7, including rat recombinant IL-7, is produced using recombinant DNA technology. It is used in various research applications to study its effects on immune cells and its potential therapeutic uses. Clinical trials of recombinant IL-7 have demonstrated its safety and potent immune reconstitution effects . Recombinant IL-7 has been explored for its potential in cancer immunotherapy, as it can enhance the proliferation and survival of T cells, which are crucial for anti-tumor responses .
IL-7 has shown promise in various therapeutic applications, particularly in the field of cancer immunotherapy. It has been used to enhance the immune response in patients with cancer by promoting the proliferation and survival of T cells . Additionally, IL-7 has been investigated for its potential to improve immune reconstitution in patients undergoing bone marrow transplantation and those with HIV/AIDS .
