IL7R Human
IL7R, Interleukin 7 Receptor, IL-7 Receptor Subunit Alpha, IL-7R Subunit Alpha,CD127 Antigen, IL-7R-Alpha, CDW127, Interleukin-7 Receptor Subunit Alpha, Interleukin 7 Receptor Isoform H5-6, Interleukin 7 Receptor Alpha Chain, IL-7RA,CD127, IL7RA, ILRA.
Greater than 90.0% as determined by SDS-PAGE.
Description
IL7R produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 461 amino acids (21-239a.a.) and having a molecular mass of 52.5kDa. (Molecular size on SDS-PAGE will appear at approximately 50-70kDa). IL7R is expressed with an 242 amino acid hIgG-His tag at C-Terminus and purified by proprietary chromatographic techniques.
Product Specs
IL7R, Interleukin 7 Receptor, IL-7 Receptor Subunit Alpha, IL-7R Subunit Alpha,CD127 Antigen, IL-7R-Alpha, CDW127, Interleukin-7 Receptor Subunit Alpha, Interleukin 7 Receptor Isoform H5-6, Interleukin 7 Receptor Alpha Chain, IL-7RA,CD127, IL7RA, ILRA.
ADLESGYAQN GDLEDAELDD YSFSCYSQLE VNGSQHSLTC AFEDPDVNIT NLEFEICGAL VEVKCLNFRK LQEIYFIETK KFLLIGKSNI CVKVGEKSLT CKKIDLTTIV KPEAPFDLSV VYREGANDFV VTFNTSHLQK KYVKVLMHDV AYRQEKDENK WTHVNLSSTK LTLLQRKLQP AAMYEIKVRS IPDHYFKGFW SEWSPSYYFR TPEINNSSGE MDLEPKSCDK THTCPPCPAP ELLGGPSVFL FPPKPKDTLM ISRTPEVTCV VVDVSHEDPE VKFNWYVDGV EVHNAKTKPR EEQYNSTYRV VSVLTVLHQD WLNGKEYKCK VSNKALPAPI EKTISKAKGQ PREPQVYTLP PSRDELTKNQ VSLTCLVKGF YPSDIAVEWE SNGQPENNYK TTPPVLDSDG SFFLYSKLTV DKSRWQQGNV FSCSVMHEAL HNHYTQKSLS LSPGKHHHHH H
Product Science Overview
Interleukin-7 (IL-7) is a crucial cytokine involved in the development and maintenance of the immune system. It plays a significant role in the proliferation and survival of T cells and B cells. The Interleukin-7 Receptor (IL-7R) is a heterodimeric complex that consists of the IL-7 receptor alpha chain (IL-7Rα or CD127) and the common gamma chain (γc), which is shared with other cytokine receptors such as IL-2, IL-4, IL-9, IL-15, and IL-21 .
IL-7Rα is a 75 kDa protein that belongs to the hematopoietic receptor superfamily. It is expressed on various immune cells, including early thymocytes, T cells, pre-B cells, and bone marrow macrophages . The binding of IL-7 to its receptor triggers a cascade of signaling pathways that are essential for lymphocyte differentiation, proliferation, and survival .
IL-7 is produced by non-hematopoietic stromal cells in the bone marrow, thymus, and other lymphoid organs and tissues . It acts as a growth factor for T cells and is critical for the maintenance of naive and memory T cells. IL-7 also has anti-apoptotic properties, which help in the survival of these cells .
Recombinant human IL-7 is a synthetic form of the cytokine that is used in various research and clinical applications. It is produced using recombinant DNA technology and is optimized for use in cell culture, functional assays, and differentiation studies . Recombinant IL-7 has been shown to restore and maintain lymphocyte counts, including both CD4+ and CD8+ T cells, thereby increasing the numbers of functional T cells .
Clinical trials of recombinant IL-7 have demonstrated its safety and potent immune reconstitution effects. It has been used to enhance immune responses in patients with immunodeficiency disorders and in those undergoing treatments that deplete immune cells . The exact mechanism of action of recombinant IL-7 is still under investigation, but its ability to boost T cell numbers and function makes it a promising candidate for various therapeutic applications .
