IL1R2 Human
Sf9, Insect cells.
IL1R2, CD121b, CDw121b, IL-1R-2, IL-1RT-2, IL-1RT2, IL1R2c, IL1RB, IL-1 type II receptor, Interleukin-1 receptor beta, CD121 antigen-like family member B.
Greater than 90% as determined by SDS-PAGE.
Description
IL1R2 produced in Sf9 Insect cells is a single, glycosylated polypeptide chain containing 338 amino acids (14-343a.a.) and having a molecular mass of 38.8kDa (Molecular size on SDS-PAGE will appear at approximately 40-57kDa).
IL1R2 is expressed with an 8 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.
Product Specs
IL1R2, CD121b, CDw121b, IL-1R-2, IL-1RT-2, IL-1RT2, IL1R2c, IL1RB, IL-1 type II receptor, Interleukin-1 receptor beta, CD121 antigen-like family member B.
Sf9, Insect cells.
FTLQPAAHTG AARSCRFRGR HYKREFRLEG EPVALRCPQV PYWLWASVSP RINLTWHKND SARTVPGEEE TRMWAQDGAL WLLPALQEDS GTYVCTTRNA SYCDKMSIEL RVFENTDAFL PFISYPQILT LSTSGVLVCP DLSEFTRDKT DVKIQWYKDS LLLDKDNEKF LSVRGTTHLL
VHDVALEDAG YYRCVLTFAH EGQQYNITRS IELRIKKKKE ETIPVIISPL KTISASLGSR LTIPCKVFLG TGTPLTTMLW WTANDTHIES AYPGGRVTEG PRQEYSENNE NYIEVPLIFD PVTREDLHMD FKCVVHNTLS FQTLRTTVKE LEHHHHHH.
Product Science Overview
IL-1R2 is structurally similar to IL-1R1 but lacks the Toll/IL-1 receptor (TIR) domain in its cytoplasmic region, which is essential for signal transduction . As a result, IL-1R2 cannot transduce signals and instead functions as a decoy receptor. By binding to IL1A, IL1B, and IL1Ra, IL-1R2 prevents these cytokines from interacting with their signaling receptors, thereby inhibiting their biological activities .
The primary role of IL-1R2 is to modulate the immune response by neutralizing the effects of IL1A and IL1B. This decoy receptor mechanism is crucial in regulating inflammation and preventing excessive immune responses . IL-1R2 is expressed in various tissues, including the immune system, and its expression can be induced by interleukin-4 (IL4), which further enhances its anti-inflammatory properties .
Recombinant human IL-1R2 is produced using recombinant DNA technology, which involves inserting the IL1R2 gene into a suitable expression system, such as bacteria or mammalian cells. This allows for the large-scale production of IL-1R2 protein, which can be used for research and therapeutic purposes .
Recombinant IL-1R2 has several applications in biomedical research and clinical settings:
- Research Tool: It is used to study the mechanisms of cytokine signaling and the regulation of immune responses.
- Therapeutic Potential: Due to its ability to neutralize IL1A and IL1B, recombinant IL-1R2 has potential therapeutic applications in treating inflammatory diseases and conditions characterized by excessive cytokine activity .
