IL 17 Mouse

Interleukin-17 (IL-17) is a proinflammatory cytokine produced by activated T cells. It plays a crucial role in the immune response by regulating the activities of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) and mitogen-activated protein kinases (MAPKs). IL-17 is involved in the defense against pathogens and the regulation of inflammatory responses.

Recombinant mouse IL-17 is typically produced in Escherichia coli (E. coli) and is available in a lyophilized powder form. The recombinant protein is a homodimeric, non-glycosylated polypeptide chain containing a total of 268 amino acids and has a molecular mass of approximately 30 kDa . The protein is purified using proprietary chromatographic techniques to ensure high purity and activity.

IL-17 is known to induce the production of other cytokines such as IL-6, IL-8, and granulocyte-colony stimulating factor (G-CSF) by fibroblasts . These cytokines have significant effects on hematopoiesis, the process by which blood cells are formed. IL-17 also stimulates the expression of cyclooxygenase-2 (COX-2) and enhances the production of nitric oxide (NO), which are important mediators of inflammation .

IL-17 has been implicated in various inflammatory and autoimmune diseases. For example, in rheumatoid arthritis, IL-17 is responsible for the inflammation and destruction of joints . It is also involved in the pathogenesis of other conditions such as psoriasis, multiple sclerosis, and inflammatory bowel disease.

Recombinant mouse IL-17 is widely used in research to study its role in immune responses and disease mechanisms. It is used in cell culture experiments to investigate the signaling pathways activated by IL-17 and its effects on various cell types. The protein is also used in animal models to study the therapeutic potential of targeting IL-17 in inflammatory diseases.