IL 17E Rat

Interleukin-17E (IL-17E), also known as IL-25, is a member of the IL-17 cytokine family, which includes six structurally related cytokines: IL-17A, IL-17B, IL-17C, IL-17D, IL-17E, and IL-17F . These cytokines play crucial roles in immune regulation and inflammation. IL-17E is unique among its family members due to its ability to promote Th2-biased immune responses, contrasting with the Th1- and Th17-biased inflammation promoted by other IL-17 family members .

IL-17E was first identified in the early 2000s. It shares a conserved cysteine-rich region with other IL-17 family members, which is essential for its biological activity . Despite its structural similarities with other IL-17 cytokines, IL-17E exhibits only 16% sequence homology with IL-17A .

IL-17E is primarily involved in promoting Th2-type immune responses. It stimulates the production of cytokines such as IL-4, IL-5, and IL-13, which are associated with allergic reactions and helminth infections . This cytokine also plays a role in enhancing the production of IgE, a key antibody in allergic responses .

IL-17E has been implicated in various diseases, particularly those involving allergic inflammation and asthma. Its ability to promote Th2 responses makes it a potential therapeutic target for conditions characterized by excessive Th2 activity . Additionally, IL-17E has been studied for its role in autoimmune diseases and cancer, although its functions in these contexts are less well understood compared to other IL-17 family members .

Recombinant IL-17E (Rat) is a laboratory-produced version of the natural cytokine, used in research to study its biological functions and potential therapeutic applications. By using recombinant IL-17E, researchers can investigate its effects on immune cells and its role in various disease models, providing valuable insights into its mechanisms of action and potential clinical uses.