IL 12 p35 Human

The IL-12 p35 subunit is a single polypeptide chain consisting of 197 amino acids. It is produced by various immune cells, including dendritic cells, macrophages, and B cells, in response to pathogens and other immune stimuli . The recombinant form of IL-12 p35 is typically produced in E. coli and purified using chromatographic techniques .

IL-12 is a key player in the immune response, particularly in the activation and differentiation of T helper 1 (Th1) cells. The p35 subunit, in combination with the p40 subunit, stimulates the production of interferon-gamma (IFN-γ) by T cells and NK cells. This cytokine is essential for the immune system’s ability to combat intracellular pathogens, such as viruses and certain bacteria .

Due to its pivotal role in the immune response, IL-12 has been studied extensively for its potential therapeutic applications. It has shown promise in enhancing immune responses against infections and tumors, as well as modulating inflammatory responses in autoimmune diseases . Recombinant IL-12 p35 is used in research to better understand these mechanisms and to develop potential treatments.

Recombinant IL-12 p35 is widely used in scientific research to study its effects on immune cells and its potential therapeutic applications. It is available in various forms, including lyophilized powders and solutions, and is often used in functional assays to evaluate its biological activity .

In summary, Interleukin-12 p35 (Human Recombinant) is a vital component of the immune system with significant implications for research and therapy. Its ability to modulate immune responses makes it a valuable tool in the study of infectious diseases, cancer, and autoimmune disorders.