IGF1 PAT6F8AT Antibody
Description
Product Specs
Product Science Overview
Insulin-Like Growth Factor-1 (IGF-1) is a protein that plays a crucial role in growth and development. It is structurally similar to insulin and is involved in cellular growth, differentiation, and survival. The IGF-1 receptor (IGF-1R) is a transmembrane receptor that mediates the effects of IGF-1 by activating intracellular signaling pathways such as the PI3K/Akt and MAPK pathways .
Clone PAT6F8AT is a monoclonal antibody derived from mouse that specifically targets human IGF-1. Monoclonal antibodies are laboratory-produced molecules engineered to serve as substitute antibodies that can restore, enhance, or mimic the immune system’s attack on cells. They are designed to bind to specific targets, in this case, IGF-1.
The binding of Clone PAT6F8AT to IGF-1 inhibits the interaction between IGF-1 and its receptor, IGF-1R. This blockade prevents the activation of downstream signaling pathways that are crucial for cell growth and survival. By inhibiting these pathways, Clone PAT6F8AT can reduce the proliferative and survival capabilities of cells that rely on IGF-1 signaling .
- Cancer Research: IGF-1 and IGF-1R are often overexpressed in various types of cancer, including breast, prostate, and lung cancers. The inhibition of IGF-1 signaling by Clone PAT6F8AT can lead to reduced tumor growth and increased apoptosis (programmed cell death) in cancer cells .
- Metabolic Disorders: IGF-1 is also involved in metabolic processes. Research into IGF-1 and its inhibitors can provide insights into metabolic disorders such as diabetes and obesity .
- Growth Disorders: IGF-1 is essential for normal growth and development. Studying the effects of IGF-1 inhibition can help understand growth disorders and develop potential treatments .
