IGF1 Antibody
Insulin-Like Growth Factor-1, Mouse Anti-Human
Cat. No.
BT6116
Source
Synonyms
Somatomedin C, IGF-I, IGFI, IGF1, IGF-IA, Mechano growth factor, MGF.
Appearance
Purity
Usage
THE BioTek's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
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In Stock 
Description
Product Specs
Introduction
The insulin-like growth factors (IGFs), also known as somatomedins, are a family of peptides that play a crucial role in mammalian growth and development. IGF1 is a key mediator of growth hormone's (GH) growth-promoting effects. Initial research indicated that growth hormone's impact on cartilage sulfate incorporation wasn't direct but rather mediated through a serum factor called 'sulfation factor,' later renamed 'somatomedin.' Three primary somatomedins have been identified: somatomedin C (IGF1), somatomedin A (IGF2), and somatomedin B.
Formulation
The antibody is supplied as a 1 mg/ml solution in phosphate-buffered saline (PBS) after reconstitution.
Storage Procedures
Store the lyophilized antibody at 4°C. Following reconstitution, it is recommended to aliquot the antibody and store it at -20°C if not intended for use within one month.
Solubility
To reconstitute, add deionized water to the vial. Gently mix the solution, ensuring the sides of the vial are washed, and allow 30-60 seconds for complete dissolution before use.
Applications
This antibody is suitable for use in various applications, including direct ELISA, Western blotting, and immunoprecipitation.
Titer
In a direct ELISA setup, a 1:10,000 dilution of the antibody exhibits an optical density (OD) of 0.5 when using alkaline phosphatase-conjugated rabbit anti-mouse immunoglobulin G (IgG) from Jackson Laboratories.
Synonyms
Somatomedin C, IGF-I, IGFI, IGF1, IGF-IA, Mechano growth factor, MGF.
Purification Method
Boric acid precipitation
Type
Mouse Anti Human Monoclonal.
Clone
NYRhIGF1
Immunogen
r.Human Growth Hormone
Ig Subclass
Mouse IgM
Product Science Overview
Role and Function of IGF-1
IGF-1 is essential for normal growth and development, particularly during childhood. It promotes the growth of bones and tissues by stimulating the proliferation of cells and inhibiting apoptosis (programmed cell death). IGF-1 also plays a role in muscle growth and repair, making it a critical factor in maintaining muscle mass and function.
IGF-1 in Research and Medicine
Mouse Anti-Human IGF-1 Antibodies
Mouse anti-human IGF-1 antibodies are monoclonal antibodies produced by immunizing mice with human IGF-1. These antibodies are used in various research applications to detect and quantify IGF-1 levels in human samples. They are essential tools in studying the role of IGF-1 in different physiological and pathological conditions.
Applications of Mouse Anti-Human IGF-1 Antibodies
- Diagnostic Research: These antibodies are used in diagnostic assays to measure IGF-1 levels in blood samples, which can help diagnose growth disorders and other conditions related to abnormal IGF-1 levels.
- Therapeutic Research: Researchers use these antibodies to study the effects of IGF-1 in various diseases, including cancer, diabetes, and neurodegenerative diseases. By understanding how IGF-1 interacts with its receptors and other molecules, scientists can develop targeted therapies to modulate its activity.
- Basic Research: In basic research, mouse anti-human IGF-1 antibodies are used to investigate the molecular mechanisms underlying IGF-1’s effects on cell growth, differentiation, and survival. This research can lead to new insights into the fundamental processes of cell biology and development.
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