HOMER2 Human
Homer Homolog-2 Human Recombinant
Cat. No.
BT22388
Source
E.coli.
Synonyms
Homer homolog 2 (Drosophila), homer neuronal immediate early gene 2, homer homolog 3, HOMER-2 (2A/2B), Vesl-2, ACPD, Cupidin, CPD.
Appearance
Sterile Filtered colorless solution.
Purity
Greater than 85% as determined by SDS-PAGE.
Usage
THE BioTek's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
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In Stock 
Description
HOMER2 Human Recombinant produced in E. coli is a single polypeptide chain containing 368 amino acids (1-343) and having a molecular mass of 42.1kDa.
HOMER2 is fused to a 25 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
HOMER2 is fused to a 25 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Product Specs
Introduction
HOMER2, a member of the homer family of dendritic proteins, acts as an immediate early gene product. It exhibits binding affinity for group 1 metabotropic glutamate receptors (mGluRs), which are involved in intracellular calcium release. Furthermore, HOMER2 links mGluRs to inositol triphosphate receptors (IP3R).
Description
Recombinant HOMER2, of human origin, is produced in E. coli. This single polypeptide chain encompasses 368 amino acids (residues 1-343) and exhibits a molecular weight of 42.1kDa. The protein is engineered with a 25 amino acid His-tag at the N-terminus and undergoes purification using proprietary chromatographic techniques.
Physical Appearance
Clear, colorless solution, sterile-filtered.
Formulation
The HOMER2 solution is provided at a concentration of 0.5mg/ml in a buffer consisting of 20mM Tris-HCl (pH 8.0), 0.1M NaCl, 1mM DTT, and 10% glycerol.
Stability
For short-term storage (2-4 weeks), maintain the product at 4°C. For extended storage, freeze at -20°C. The addition of a carrier protein (0.1% HSA or BSA) is recommended for long-term storage. Repeated freeze-thaw cycles should be avoided.
Purity
Purity exceeds 85% as determined by SDS-PAGE analysis.
Synonyms
Homer homolog 2 (Drosophila), homer neuronal immediate early gene 2, homer homolog 3, HOMER-2 (2A/2B), Vesl-2, ACPD, Cupidin, CPD.
Source
E.coli.
Amino Acid Sequence
MGSSHHHHHH SSGLVPRGSH MGSHMMGEQP IFTTRAHVFQ IDPNTKKNWM PASKQAVTVS YFYDVTRNSY RIISVDGAKV IINSTITPNM TFTKTSQKFG QWADSRANTV FGLGFSSEQQ LTKFAEKFQE VKEAAKIAKD KTQEKIETSS NHSQASSVNG TDDEKASHAG PANTHLKSEN DKLKIALTQS AANVKKWEIE LQTLRESNAR LTTALQESAA SVEQWKRQFS ICRDENDRLR NKIDELEEQC SEINREKEKN TQLKRRIEEL EAELREKETE LKDLRKQSEI IPQLMSECEY VSEKLEAAER DNQNLEDKVR SLKTDIEESK YRQRHLKVEL KSFLEVLDGK IDDLHDFRRG LSKLGTDN
Product Science Overview
Structure and Expression
HOMER2 is expressed in various tissues, including the brain, heart, kidney, muscle, ovary, and testicles . The protein consists of an N-terminal EVH1 domain, which is responsible for binding to proline-rich motifs in target proteins, and a coiled-coil domain that mediates self-association and the formation of multimeric complexes .
Function
HOMER2 is involved in several key physiological processes:
- Synaptic Plasticity: HOMER2 contributes to the integrity and proper function of synapses by regulating the size and strength of synaptic connections. This regulation is essential for learning, memory formation, and other cognitive functions .
- Calcium Signaling: HOMER2 links mGluRs with inositol triphosphate receptors (IP3R), facilitating the release of intracellular calcium stores. This interaction is crucial for various cellular processes, including neurotransmitter release and muscle contraction .
- Homeostasis: HOMER2 plays a role in maintaining homeostasis in the nervous system by modulating synaptic activity and preventing excitotoxicity, which can lead to neuronal damage .
Recombinant HOMER2
Clinical Implications
Dysregulation of HOMER2 has been implicated in several neurological and psychiatric disorders, including:
- Addiction: Altered HOMER2 expression has been linked to changes in synaptic plasticity associated with addictive behaviors .
- Anxiety and Autism: Overexpression of HOMER2 in certain brain regions can induce anxiety-like behaviors and contribute to the development of autism spectrum disorders .
- Neurodegenerative Diseases: HOMER2 dysregulation may play a role in the pathogenesis of diseases such as Alzheimer’s and Amyotrophic Lateral Sclerosis (ALS) .
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