HIV-1 p24 gag
Description
The HIV-1 p24 gag is fused to beta-galactosidase (114 kDa).
Product Specs
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Product Science Overview
The HIV-1 p24 Gag protein is a crucial component of the Human Immunodeficiency Virus type 1 (HIV-1), playing a significant role in the virus’s life cycle. The recombinant form of this protein is widely used in research and diagnostic applications due to its importance in the assembly and maturation of the virus.
The Gag gene of HIV-1 encodes a precursor polyprotein known as Pr55Gag. This precursor is cleaved by the viral protease to produce several smaller proteins, including p17, p24, p7, and p6 . Among these, p24 is a major structural protein of the viral core, essential for the formation of the virus particle .
During the viral assembly process, the p24 protein performs complex tasks, including membrane association and self-association, which ultimately lead to the budding of an immature virion from the infected cell . This process is critical for the production of new virus particles and the spread of the infection.
The detection of HIV-1 p24 antigen is a key method for the early identification of primary HIV infection. This early detection allows for timely intervention to limit the spread of the virus . Recombinant forms of the p24 protein are used in various diagnostic tests to evaluate their sensitivity and specificity in detecting HIV-1 .
