HDAC2 Human
Description
The HDAC2 is fused to an 8 amino acid His-Tag at C-terminus and purified by proprietary chromatographic techniques.
Product Specs
GDGVEEAFYT TDRVMTVSFH KYGEYFPGTG DLRDIGAGKG KYYAVNFPMR DGIDDESYGQ IFKPIISKVM EMYQPSAVVL QCGADSLSGD RLGCFNLTVK GHAKCVEVVK TFNLPLLMLG GGGYTIRNVA RCWTYETAVA LDCEIPNELP YNDYFEYFGP DFKLHISPSN MTNQNTPEYM
EKIKQRLFEN LRMLPHAPGV QMQAIPEDAV HEDSGDEDGE DPDKRISIRA SDKRIACDEE FSDSEDEGEG GRRNVADHKK GAKKARIEED KKETEDKKTD VKEEDKSKDN SGEKTDTKGT KSEQLSNPSR HHHHHH
Product Science Overview
HDAC2 is part of the histone deacetylase complex and is primarily located in the nucleus . The enzyme functions by binding to nucleosomal DNA and removing acetyl groups from histones, leading to a more condensed chromatin structure and reduced gene expression . This activity is essential for maintaining the balance between acetylation and deacetylation, which is critical for proper cellular function .
HDAC2 is involved in a wide range of biological processes, including:
- Transcriptional Regulation: By deacetylating histones, HDAC2 represses gene expression .
- Cell Cycle Progression: HDAC2 plays a role in the regulation of the cell cycle, ensuring proper cell division and growth .
- Developmental Events: The enzyme is crucial for various developmental processes, including embryonic development and differentiation .
HDAC2 has been implicated in several diseases and conditions:
- Cancer: Aberrant expression or activity of HDAC2 is associated with various cancers. HDAC inhibitors are being explored as potential therapeutic agents for cancer treatment .
- Neurodegenerative Diseases: HDAC2 is involved in the pathogenesis of neurodegenerative diseases such as Alzheimer’s and Parkinson’s .
- Cardiac Hypertrophy: HDAC2 plays a role in the development of cardiac hypertrophy, a condition characterized by the thickening of the heart muscle .
Given its involvement in multiple diseases, HDAC2 is a target for therapeutic intervention. HDAC inhibitors (HDACi) are being developed and tested for their efficacy in treating cancer, neurodegenerative diseases, and other conditions . These inhibitors work by blocking the deacetylase activity of HDAC2, thereby restoring normal acetylation levels and gene expression patterns .
Recombinant HDAC2 refers to the enzyme produced through recombinant DNA technology. This involves inserting the HDAC2 gene into a suitable expression system, such as bacteria or mammalian cells, to produce the enzyme in large quantities . Recombinant HDAC2 is used in research to study its structure, function, and role in various diseases, as well as to screen potential HDAC inhibitors .
