HCV NS3 47.8kDa
Description
Product Specs
Product Science Overview
Hepatitis C Virus (HCV) is a significant global health concern, infecting millions of people worldwide. The virus is known for its ability to cause chronic liver diseases, including cirrhosis and hepatocellular carcinoma. One of the critical components of HCV is the non-structural protein 3 (NS3), which plays a vital role in the virus’s replication and pathogenesis.
The NS3 protein of HCV is a multifunctional enzyme with protease and helicase activities. It is approximately 47.8 kDa in size and is essential for the cleavage of the HCV polyprotein into functional units. The protease activity of NS3 is responsible for processing the viral polyprotein, while the helicase activity is involved in unwinding the RNA during replication .
Recombinant NS3 proteins are produced using various expression systems, such as bacterial, yeast, and mammalian cells. These recombinant proteins are crucial for research and diagnostic purposes. They are used to study the enzyme’s structure and function, screen for potential inhibitors, and develop diagnostic assays for HCV infection .
- Drug Development: The NS3 protein is a target for antiviral drugs. Inhibitors of NS3 protease and helicase activities have been developed to block HCV replication. These inhibitors are a part of the direct-acting antiviral (DAA) therapies that have significantly improved the treatment outcomes for HCV-infected patients .
- Diagnostic Assays: Recombinant NS3 proteins are used in enzyme immunoassays (EIAs) to detect antibodies against HCV in patient samples. These assays are essential for the early diagnosis and management of HCV infection .
- Vaccine Development: Although there is no approved vaccine for HCV, recombinant NS3 proteins are being explored as potential vaccine candidates. They can elicit an immune response that may protect against HCV infection .
