HCV Core 22kDa
Description
The protein is fused with b-galactosidase (114 kDa) at N-terminus.
Product Specs
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Product Science Overview
Hepatitis C virus (HCV) is a significant global health concern, affecting millions of individuals worldwide. It is an enveloped, positive-sense single-stranded RNA virus belonging to the Hepacivirus genus within the Flaviviridae family . The virus’s genome encodes a single polyprotein, which is processed into ten mature proteins, including three structural proteins (core, E1, E2) and seven non-structural proteins (p7, NS2, NS3, NS4A, NS4B, NS5A, and NS5B) .
The core protein of HCV, also known as the nucleocapsid protein, plays a crucial role in the virus’s life cycle. It is involved in the formation of the viral nucleocapsid, which encapsulates the viral RNA genome. The core protein is highly conserved across different HCV genotypes, making it a target for diagnostic and therapeutic applications .
Recombinant proteins are produced through recombinant DNA technology, which involves inserting the gene encoding the protein of interest into an expression system, such as bacteria, yeast, or mammalian cells. The Hepatitis C Virus Core 22kDa Recombinant protein is a recombinant form of the HCV core protein, typically produced in an expression system to ensure high purity and yield.
The recombinant HCV core protein has several applications in research and clinical settings:
- Vaccine Development: The core protein is a potential candidate for vaccine development due to its immunogenic properties. It can elicit both humoral and cellular immune responses, making it a valuable component in vaccine formulations .
- Diagnostic Tools: The core protein is used in diagnostic assays to detect HCV infection. It can be employed in enzyme-linked immunosorbent assays (ELISAs) to identify antibodies against HCV in patient samples .
- Therapeutic Research: The recombinant core protein is used in therapeutic research to study the virus’s life cycle and develop antiviral drugs. It serves as a model protein to understand the interactions between the virus and host cells .
