GH Antibody
Description
Product Specs
Product Science Overview
Growth hormone (GH), also known as somatotropin, is a peptide hormone that stimulates growth, cell reproduction, and cell regeneration in humans and other animals. It is crucial for human development and is produced by the pituitary gland. The mouse anti-human growth hormone antibody is a monoclonal antibody developed in mice that specifically targets human growth hormone. This antibody is widely used in research and diagnostic applications.
Growth hormone is a 191-amino acid, single-chain polypeptide that is synthesized, stored, and secreted by somatotropic cells within the lateral wings of the anterior pituitary gland. GH plays a key role in growth, metabolism, and overall health. It stimulates the liver and other tissues to secrete insulin-like growth factor 1 (IGF-1), which in turn promotes the growth of bones and other tissues.
The secretion of growth hormone is regulated by the hypothalamus, which releases growth hormone-releasing hormone (GHRH) to stimulate GH release and somatostatin to inhibit it. Factors such as sleep, stress, exercise, and nutrition can influence GH levels. GH secretion follows a pulsatile pattern, with the highest levels occurring during sleep.
The mouse anti-human growth hormone antibody is a monoclonal antibody produced by immunizing mice with human growth hormone. This antibody is designed to specifically bind to human GH, allowing for its detection and quantification in various assays. Monoclonal antibodies are preferred in research due to their high specificity and consistency.
Mouse anti-human growth hormone antibodies are used in a variety of scientific applications, including:
- Western Blotting (WB): To detect and quantify GH in protein samples.
- Enzyme-Linked Immunosorbent Assay (ELISA): For the quantitative measurement of GH in biological samples.
- Immunohistochemistry (IHC): To visualize GH distribution in tissue sections.
- Immunocytochemistry (ICC): To detect GH in cultured cells.
- Immunoprecipitation (IP): To isolate GH from complex mixtures.
These antibodies are essential tools in endocrinology research, particularly in studies related to growth disorders, pituitary function, and metabolic diseases.
