GM CSF Mouse

Granulocyte Macrophage-Colony Stimulating Factor (GM-CSF) is a monomeric glycoprotein that functions as a cytokine. It is a crucial white blood cell growth factor that stimulates stem cells to produce granulocytes (neutrophils, eosinophils, and basophils) and monocytes . These monocytes exit the circulation and migrate into tissues, where they mature into macrophages and dendritic cells .

GM-CSF plays a significant role in hematopoiesis, the process of forming new blood cells. It is essential for the proliferation and development of granulocyte and monocyte/macrophage progenitors . Additionally, GM-CSF functions as a growth factor for erythroid and megakaryocytic precursor cells in conjunction with erythropoietin .

In the immune system, GM-CSF promotes the survival and activation of macrophages, neutrophils, and eosinophils, as well as the maturation of dendritic cells . It also enhances pro-inflammatory cytokine production, antigen presentation, phagocytosis, and leukocyte chemotaxis and adhesion . GM-CSF can polarize macrophages into M1-like inflammatory macrophages, which produce a variety of inflammatory cytokines and promote Th1-Th17 responses .

Recombinant GM-CSF, including mouse recombinant GM-CSF, is produced using genetic engineering techniques. The gene encoding GM-CSF is inserted into an expression vector, which is then introduced into a host cell line. The host cells express the GM-CSF protein, which is subsequently purified for use in research and therapeutic applications.

Recombinant GM-CSF is widely used in research to study its effects on various cell types and its role in immune responses. It is also used in preclinical studies to investigate potential therapeutic applications. In medicine, GM-CSF has been explored as a therapeutic target for autoimmune diseases due to its pro-inflammatory functions . Clinical trials targeting GM-CSF in autoimmune diseases, such as rheumatoid arthritis, have shown promising results with significant efficacy and minimal side effects .