Natural Proteins
Product List
Fibronectin Human
Fibronectin Human
Human Fibronectin produced purified from Human Plasma having a Molecular Weight of 440kDa.
Filtered White lyophilized (freeze-dried) powder.
Fibronectin Rat
Fibronectin Rat
Fibronectin Recombinant
Fibronectin Human Recombinant
Fibronectin Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 574 amino acids and having a molecular mass of 62.6kDa. The Fibronectin is purified by proprietary chromatographic techniques.
Escherichia Coli.
Introduction
Fibronectin is a high-molecular-weight glycoprotein of the extracellular matrix that binds to membrane-spanning receptor proteins called integrins. It also binds to other extracellular matrix proteins such as collagen, fibrin, and heparan sulfate proteoglycans . Fibronectin exists as a protein dimer, consisting of two nearly identical monomers linked by a pair of disulfide bonds . There are two main types of fibronectin in vertebrates: soluble plasma fibronectin, which is a major protein component of blood plasma, and insoluble cellular fibronectin, which is a major component of the extracellular matrix .
Fibronectin plays a crucial role in cell adhesion, growth, migration, and differentiation . It is expressed in various tissues and is essential for processes such as wound healing and embryonic development . Plasma fibronectin is produced in the liver by hepatocytes, while cellular fibronectin is secreted by various cells, primarily fibroblasts . The expression patterns of fibronectin can vary, and its levels are often altered in response to tissue injury or disease .
Fibronectin is involved in several key biological functions, including cell adhesion, growth, migration, and differentiation . It plays a significant role in wound healing and embryonic development . Additionally, fibronectin is involved in immune responses and pathogen recognition, as it can bind to various pathogens, including viruses, bacteria, fungi, and protozoa . This binding helps in the clearance of pathogens from the body and supports the immune system’s response to infections .
Fibronectin interacts with other molecules and cells through specific domains that promote cell-to-cell adhesion, cell-to-basement-membrane attachment, and clot stabilization . It binds to integrin receptors on cell surfaces, which triggers downstream signaling cascades that regulate cell behavior . Fibronectin also plays a role in embryogenesis, nerve regeneration, fibroblast migration, and macrophage function . The shift from soluble to insoluble fibronectin fibrils occurs when cryptic fibronectin-binding sites are exposed along the length of a bound fibronectin molecule .
The expression and activity of fibronectin are regulated by various mechanisms, including transcriptional regulation and post-translational modifications . During extracellular matrix (ECM) assembly and turnover, cells upregulate the assembly of fibronectin into viscoelastic fibrils that can bind numerous growth factors and cytokines . These fibrils play a key role in assembling a provisional ECM during embryonic development and wound healing . Additionally, fibronectin expression can be influenced by factors such as tissue injury, inflammation, and disease .
Fibronectin has several applications in biomedical research, diagnostic tools, and therapeutic strategies . It is used in tissue engineering and regenerative medicine to promote cell adhesion and tissue repair . Fibronectin-enriched biomaterials are employed to enhance the biological responses at implant sites . In oncology, fibronectin serves as a prognostic and theranostic marker, aiding in cancer diagnosis and therapy . Its role in wound healing and tissue repair also makes it a valuable component in various medical treatments .
Throughout the life cycle, fibronectin plays a vital role in development, aging, and disease . During embryonic development, fibronectin is essential for cell migration and tissue organization . In adulthood, it continues to support tissue repair and regeneration . Altered fibronectin expression and organization are associated with various pathologies, including cancer, arthritis, and fibrosis . As organisms age, changes in fibronectin levels and function can impact tissue integrity and contribute to age-related diseases .
