FABP4 Antibody

Fatty Acid Binding Protein 4 (FABP4), also known as adipocyte fatty acid-binding protein (A-FABP), is a member of the fatty acid-binding protein family. These proteins are involved in the intracellular transport of long-chain fatty acids and other lipophilic substances. FABP4 is predominantly expressed in adipocytes and macrophages, playing a crucial role in lipid metabolism and energy homeostasis .

FABP4 has been implicated in various metabolic and inflammatory processes. It is known to influence insulin sensitivity, lipid metabolism, and inflammatory responses. Elevated levels of FABP4 are associated with metabolic disorders such as obesity, type 2 diabetes, and cardiovascular diseases . Additionally, FABP4 has been linked to reproductive health, affecting maternal-fetal interface homeostasis and pregnancy outcomes .

The development of mouse anti-human FABP4 antibodies has been a significant advancement in biomedical research. These antibodies are used to study the function and regulation of FABP4 in various physiological and pathological conditions. They are also employed in diagnostic and therapeutic applications, particularly in the context of metabolic and inflammatory diseases .

The preparation of mouse anti-human FABP4 antibodies typically involves immunizing mice with recombinant human FABP4 protein. The immune response generates specific antibodies against FABP4, which are then harvested and purified. Hybridoma technology is often used to produce monoclonal antibodies, ensuring high specificity and consistency .

Mouse anti-human FABP4 antibodies are valuable tools in research for investigating the role of FABP4 in metabolic and inflammatory pathways. They are used in various assays, including Western blotting, immunohistochemistry, and ELISA, to detect and quantify FABP4 levels in biological samples. In medicine, these antibodies have potential therapeutic applications, such as targeting FABP4 to treat obesity-related breast cancer .