CMV Mosaic
CMV Mosaic is >85% pure as determined by 12% PAGE (coomassie staining).
Description
The E.Coli derived Recombinant Cytomegalo Virus Mosaic contains the multiple epitopes from P150-P52-P38-P65-P28 having a molecular weight of 40kDa.
The CMV Mosaic is fused to a 6xHis tag and purified by proprietary chromatographic technique.
Product Specs
Product Science Overview
Cytomegalovirus (CMV) is a member of the herpesvirus family, known for its large genome of approximately 230 kb encoding 160 genes . CMV infection is widespread, with a significant portion of the adult population being seropositive. In the United States, around 60% of adults are infected with CMV . The virus is associated with various pathological conditions, including retinitis, pneumonia, hepatitis, and encephalitis, and can be transmitted congenitally, horizontally, and parenterally .
The term “CMV mosaic recombinant” refers to a recombinant protein that contains immunodominant regions of the CMV glycoprotein B (gB). This protein is often used in research and diagnostic applications due to its immunoreactivity with sera from CMV-infected individuals . The CMV gB mosaic recombinant protein is typically produced in E. coli and is fused to tags such as GST, 6 His, and S-tag for purification and detection purposes .
The CMV gB mosaic recombinant protein is primarily used in enzyme-linked immunosorbent assays (ELISA) to detect anti-CMV antibodies in sera samples . This protein’s immunodominant regions make it highly specific and sensitive for serological detection, providing a robust method for studying CMV infection . Additionally, CMV-based vaccine candidates have been explored for cancer immunotherapy, utilizing recombinant CMV vectors to express tumor-associated antigens .
