CFB-a Human
Complement Factor B Fragment a Human
Cat. No.
BT18394
Source
Human Plasma.
Synonyms
Complement factor B (EC:3.4.21.47), C3/C5 convertase, Glycine-rich beta glycoprotein, GBG, PBF2, Properdin factor B, Complement factor B Ba fragment, Complement factor B Bb fragment, CFB, Complement Factor B, BFD, AHUS4, BF, BFD, CFAB, FB, FBI12, H2-Bf.
Appearance
Sterile filtered solution.
Purity
Greater than 95.0% as determined by SDS-PAGE.
Usage
THE BioTek's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
Shipped with Ice Packs 
In Stock 
Description
CFB-a Human produced in Human Plasma having a molecular mass of 33 kDa.
Product Specs
Introduction
Complement Factor B, also known as CFB, encodes complement factor B, a component of the complement system's alternative pathway. Factor B, circulating in the blood as a single-chain polypeptide, is cleaved by complement factor D upon activation of the alternative pathway. This cleavage yields the noncatalytic chain Ba and the catalytic subunit Bb. The active subunit Bb, a serine protease, binds with C3b, forming the alternative pathway C3 convertase. Bb also plays a role in the proliferation of preactivated B lymphocytes, while Ba inhibits their proliferation.
Description
CFB-a is a human-derived protein produced in human plasma, with a molecular mass of 33 kDa.
Physical Appearance
Sterile filtered solution.
Formulation
CFB-a solution (1mg/ml) is supplied in Phosphate-buffered saline, pH 7.2.
Stability
CFB-a Human is stable at 4°C for 2-4 weeks, provided the entire vial is used within this period. For extended storage, freeze below -20°C. Adding a carrier protein (0.1% HSA or BSA) is recommended for long-term storage. Avoid repeated freeze-thaw cycles.
Purity
Greater than 95.0% purity as determined by SDS-PAGE.
Human Virus Test
Plasma from each donor undergoes testing to ensure it is negative for antibodies to HIV-1, HIV-2, HCV, and HBSAG.
Synonyms
Complement factor B (EC:3.4.21.47), C3/C5 convertase, Glycine-rich beta glycoprotein, GBG, PBF2, Properdin factor B, Complement factor B Ba fragment, Complement factor B Bb fragment, CFB, Complement Factor B, BFD, AHUS4, BF, BFD, CFAB, FB, FBI12, H2-Bf.
Source
Human Plasma.
Product Science Overview
Structure and Function
- Ba Fragment: This fragment inhibits the proliferation of preactivated B-lymphocytes .
- Bb Fragment: This fragment is a serine protease that combines with Complement Factor 3b to form the C3 or C5 convertase . The Bb fragment is involved in the proliferation and differentiation of preactivated B-lymphocytes, rapid spreading of peripheral blood monocytes, stimulation of lymphocyte blastogenesis, and lysis of erythrocytes .
Gene Location
Biological Process
Preparation Methods
Chemical Reactions Analysis
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