CD86 Antibody
Description
Product Specs
Product Science Overview
CD86 is an 80 kDa protein that serves as a ligand for two important receptors on T cells: CD28 and CTLA-4 (CD152) . The interaction between CD86 and CD28 provides a co-stimulatory signal necessary for T cell activation, proliferation, and cytokine production. Conversely, the interaction between CD86 and CTLA-4 delivers an inhibitory signal that helps regulate and maintain immune homeostasis .
CD86 is expressed on the surface of APCs and is upregulated in response to inflammatory stimuli such as lipopolysaccharides (LPS). This upregulation enhances the ability of APCs to activate T cells and initiate an immune response . CD86 is expressed earlier in the immune response compared to its counterpart, CD80 (B7-1), and plays a pivotal role in the early stages of T cell activation .
The Rat Anti-Mouse CD86 antibody is widely used in immunological research to study the expression and function of CD86 in various experimental settings. This antibody is particularly useful in flow cytometry, immunohistochemistry, and immunoprecipitation assays . It helps researchers investigate the role of CD86 in T cell activation, immune regulation, and the development of immune-related diseases.
Understanding the function and regulation of CD86 is essential for developing therapeutic strategies for autoimmune diseases, cancer, and transplant rejection. Targeting the CD86-CD28/CTLA-4 pathway can modulate immune responses, making it a potential therapeutic target for various immunological disorders .
