H1N1 California
Description
Product Specs
Product Science Overview
The H1N1 Influenza Virus California/04/2009, often referred to as A/California/04/2009 (H1N1), is a significant strain of the influenza A virus. This strain gained global attention during the 2009 H1N1 pandemic, commonly known as the “swine flu” pandemic. The virus is a recombinant strain, meaning it resulted from the genetic reassortment of pre-existing influenza viruses.
The H1N1 Influenza Virus California/04/2009 emerged in April 2009 as a novel virus due to genetic reassortment between two pre-existing swine strains . This highly contagious recombinant virus contains the same genomic background as North American triple reassortant (TR) viruses, except for the neuraminidase (NA) and matrix (M) segments, which were acquired from the Eurasian swine lineage .
The virus’s structure includes several key proteins, with hemagglutinin (HA) and neuraminidase (NA) being the most notable. Hemagglutinin is responsible for the virus’s ability to bind to host cells and facilitate the entry of the viral genome into the target cells by causing the fusion of the host endosomal membrane with the viral membrane . Neuraminidase, on the other hand, helps release new viral particles from infected cells, aiding in the spread of the virus within the host .
The recombinant nature of the H1N1 Influenza Virus California/04/2009 is particularly noteworthy. The virus’s hemagglutinin (HA) and neuraminidase (NA) gene segments are derived from A/California/04/2009, while the remaining influenza viral gene segments come from A/PR/8/34 . This recombination allows the virus to possess unique properties that contribute to its virulence and transmissibility.
The 2009 H1N1 pandemic had a profound impact on global public health. The virus spread rapidly across the world, leading to widespread illness and significant mortality. The pandemic highlighted the importance of surveillance, rapid response, and vaccine development in managing influenza outbreaks. The H1N1 Influenza Virus California/04/2009 continues to be a subject of study for researchers aiming to understand its behavior, develop effective treatments, and improve preventive measures.
