C9ORF95 Human

Chromosome 9 Open Reading Frame 95 Human Recombinant
Cat. No.
BT10113
Source
Escherichia Coli.
Synonyms
Nicotinamide riboside kinase 1, NRK 1, NmR-K 1, Nicotinic acid riboside kinase 1, Ribosylnicotinamide kinase 1, RNK 1, Ribosylnicotinic acid kinase 1, NMRK1, C9orf95, NRK1, bA235O14.2, RP11-235O14.2.
Appearance
Sterile Filtered colorless solution.
Purity
Greater than 90.0% as determined by SDS-PAGE.
Usage
THE BioTek's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
Shipped with Ice Packs
In Stock
Quick Inquiry

Description

C9ORF95 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 222 amino acids (1-199 a.a) and having a molecular mass of 25.6kDa.
C9ORF95 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Product Specs

Introduction
Chromosome 9 Open Reading Frame 95 (C9ORF95/NRK1), a member of the uridine kinase family, plays a crucial role in NAD+ biosynthesis. NAD+ is essential for all living organisms, serving as a coenzyme for oxidoreductases and a source of ADPribosyl groups involved in various processes, including those linked to aging. Nicotinic acid and nicotinamide are vitamin precursors of NAD+. C9ORF95 catalyzes the phosphorylation of nicotinamide riboside (NR) and nicotinic acid riboside (NaR) to form nicotinamide mononucleotide (NMN) and nicotinic acid mononucleotide (NaMN), respectively. Additionally, C9ORF95 phosphorylates the antitumor drugs tiazofurin and 3-deazaguanosine.
Description
Recombinant human C9ORF95, expressed in E. coli, is a single, non-glycosylated polypeptide chain consisting of 222 amino acids (with amino acids 1-199 derived from C9ORF95) and possessing a molecular weight of 25.6 kDa. The protein includes a 23 amino acid His-tag at the N-terminus and is purified using proprietary chromatographic techniques.
Physical Appearance
A clear, colorless solution that has been sterilized by filtration.
Formulation
The C9ORF95 protein solution is provided at a concentration of 0.5 mg/mL in a buffer consisting of 20 mM Tris-HCl (pH 8.0), 10% glycerol, 2 mM DTT, and 200 mM NaCl.
Stability
For short-term storage (up to 2-4 weeks), the product should be kept at 4°C. For extended storage, it is recommended to freeze the protein at -20°C. The addition of a carrier protein (0.1% HSA or BSA) is advisable for long-term storage. To maintain protein integrity, avoid repeated freeze-thaw cycles.
Purity
The purity of the C9ORF95 protein is determined to be greater than 90.0% using SDS-PAGE analysis.
Synonyms
Nicotinamide riboside kinase 1, NRK 1, NmR-K 1, Nicotinic acid riboside kinase 1, Ribosylnicotinamide kinase 1, RNK 1, Ribosylnicotinic acid kinase 1, NMRK1, C9orf95, NRK1, bA235O14.2, RP11-235O14.2.
Source
Escherichia Coli.
Amino Acid Sequence
MGSSHHHHHH SSGLVPRGSH MGSMKTFIIG ISGVTNSGKT TLAKNLQKHL PNCSVISQDD FFKPESEIET DKNGFLQYDV LEALNMEKMM SAISCWMESA RHSVVSTDQE SAEEIPILII EGFLLFNYKP LDTIWNRSYF LTIPYEECKR RRSTRVYQPP DSPGYFDGHV WPMYLKYRQE
MQDITWEVVY LDGTKSEEDL FLQVYEDLIQ ELAKQKCLQV TA.

Product Science Overview

Gene and Protein Structure

The C9orf95 gene is composed of several exons and introns, which are segments of DNA that are transcribed into RNA. The exons are the coding regions that are ultimately translated into the protein, while the introns are non-coding regions that are spliced out during RNA processing. The protein encoded by C9orf95 is a recombinant protein, meaning it is produced through recombinant DNA technology, which involves inserting the gene into a host organism (such as bacteria) to produce the protein in large quantities.

Biological Function

Although the precise biological function of C9orf95 is not fully understood, it is thought to be involved in various cellular processes, including cell signaling, growth, and differentiation. Proteins encoded by ORFs like C9orf95 are often studied to understand their role in health and disease. Research on C9orf95 may provide insights into its potential involvement in certain medical conditions or its utility as a biomarker for disease.

Applications in Research and Medicine

Recombinant proteins like C9orf95 are valuable tools in scientific research and medicine. They can be used in various applications, including:

  • Functional Studies: Researchers can study the function of C9orf95 by observing the effects of its overexpression or knockdown in cell lines or animal models.
  • Drug Development: Understanding the role of C9orf95 in cellular processes can aid in the development of new therapeutic targets for diseases.
  • Diagnostic Tools: Recombinant proteins can be used to develop diagnostic assays for detecting diseases or monitoring treatment responses.

Quick Inquiry

Personal Email Detected
Please use an institutional or corporate email address for inquiries. Personal email accounts ( such as Gmail, Yahoo, and Outlook) are not accepted. *

Category

Service

Related Products

C14ORF129 Human
Chromosome 14 Open Reading Frame 129 Human Recombinant
Cat. No.
BT9238
Source
Escherichia Coli.
C20ORF20 Human
Chromosome 20 Open Reading Frame 20 Human Recombinant
Cat. No.
BT9791
Source
Escherichia Coli.
C6ORF108 Human
Chromosome 6 Open Reading Frame 108 Human Recombinant
Cat. No.
BT9867
Source
Escherichia Coli.
C12ORF5 Human, His
Chromosome 12 Open Reading Frame 5 Human Recombinant, His Tag
Cat. No.
BT13402
Source
Escherichia Coli.
THE BIOTEK
THE BioTek is a global biotech company offering highly purified proteins for research in cancer, apoptosis, development, endocrinology, immunology, neuroscience, proteases, and stem cells.
  • Contact
  • Address: 1925 E Maple Ave, El Segundo, CA 90245 United States
  • Phone : +1 201-285-7826
  • Email : info@thebiotek.com
  • Hours : Mon.-Fri. 9:00 AM - 5:00 PM
© Copyright 2024 Thebiotek. All Rights Reserved.