C1QTNF7 Human
Filtered White lyophilized (freeze-dried) powder.
Description
C1QTNF7 Human Recombinant produced in E.Coli is a signle, non-glycosylated, Polypeptide chain containing 283 amino acids and having a molecular mass of 30.22 kDa. The protein contains an extra 10 amino acid His tag at N-terminus. The C1QTNF7 amino acid sequence is identical to UniProtKB/Swiss-Prot entry Q9BXJ2 amino acids 17–289.
The C1QTNF7 is purified by proprietary chromatographic techniques.
Product Specs
Product Science Overview
Complement C1q Tumor Necrosis Factor-Related Protein 7 (CTRP7) is a member of the C1q/TNF-related protein (CTRP) family. This family consists of secreted proteins that share structural similarities with the complement component C1q and the tumor necrosis factor (TNF) superfamily. CTRPs are known for their roles in various physiological processes, including metabolism, inflammation, and immune responses .
CTRP7, like other members of the CTRP family, is composed of several distinct domains:
- N-terminal signal peptide: This sequence directs the protein to the secretory pathway.
- Variable domain: This region varies among different CTRP family members and contributes to their unique functions.
- Collagenous domain: This domain is characterized by a series of Gly-X-Y repeats, where X and Y are often proline and hydroxyproline, respectively. It is responsible for the trimerization of the protein.
- C-terminal globular C1q (gC1q) domain: This domain is homologous to the globular domain of the complement protein C1q and is crucial for the protein’s biological activity .
CTRP7 has been implicated in several biological processes:
- Metabolism: CTRP7 is involved in the regulation of lipid and glucose metabolism. It enhances insulin sensitivity and has anti-inflammatory properties, making it a potential therapeutic target for metabolic disorders such as obesity and type 2 diabetes .
- Inflammation: CTRP7 plays a role in modulating inflammatory responses. It can influence the production of pro-inflammatory cytokines and has been shown to have protective effects against inflammatory diseases .
- Immune Response: The protein is also involved in the immune response, contributing to the regulation of immune cell functions and the maintenance of immune homeostasis .
Human recombinant CTRP7 is produced using recombinant DNA technology. This involves the insertion of the gene encoding CTRP7 into an expression vector, which is then introduced into a host cell (such as E. coli or mammalian cells). The host cells express the protein, which is subsequently purified for research or therapeutic use. Recombinant production allows for the generation of large quantities of the protein with high purity and consistency .
Given its roles in metabolism and inflammation, CTRP7 is being studied for its potential therapeutic applications. It may serve as a biomarker for metabolic and inflammatory diseases and could be targeted for the development of new treatments. Research is ongoing to better understand the mechanisms by which CTRP7 exerts its effects and to explore its potential in clinical settings .
