C1QTNF2 Human
Description
His-tag.
Product Specs
Product Science Overview
Complement C1q Tumor Necrosis Factor-Related Protein 2 (CTRP2) is a member of the C1q/Tumor Necrosis Factor (TNF) superfamily. This family of proteins is characterized by their structural similarity to the complement component C1q and the TNF family. CTRP2, like other members of this family, plays a significant role in various physiological processes, including metabolism, inflammation, and immune response.
CTRP2 is a secreted protein composed of several distinct domains:
- N-terminal signal peptide: This domain is responsible for directing the protein to the secretory pathway.
- Short variable domain: This domain varies among different members of the CTRP family.
- Collagenous domain: This domain is characterized by a series of Gly-X-Y repeats, where X and Y are often proline and hydroxyproline, respectively.
- C-terminal globular domain: This domain is homologous to the globular domain of C1q and is crucial for the protein’s function.
CTRP2 is involved in several key physiological processes:
- Metabolism: CTRP2 has been shown to enhance metabolism through the activation of AMP-activated protein kinase (AMPK) and AKT-dependent pathways. It possesses insulin-sensitizing properties, making it a potential target for the treatment of metabolic disorders such as type 2 diabetes and obesity .
- Inflammation: CTRP2 plays a role in modulating inflammation. It has anti-inflammatory effects, which are beneficial in conditions characterized by chronic inflammation, such as cardiovascular diseases and non-alcoholic fatty liver disease .
- Immune Response: CTRP2 is also involved in the immune response, although its exact role in this process is still being studied.
The dysregulation of CTRP2 expression has been linked to various metabolic and inflammatory diseases. For instance, reduced levels of CTRP2 have been observed in individuals with obesity and type 2 diabetes. Conversely, increased levels of CTRP2 have been associated with improved insulin sensitivity and reduced inflammation .
Given its role in metabolism and inflammation, CTRP2 is considered a promising target for therapeutic intervention. Research is ongoing to better understand its mechanisms of action and to develop potential treatments for metabolic and inflammatory diseases. The use of human recombinant CTRP2 in research allows for the study of its effects in a controlled environment, providing valuable insights into its potential therapeutic applications .
