C1QTNF6 Human
Complement C1q Tumor Necrosis Factor-Related Protein 6 Human Recombinant
Cat. No.
BT14639
Source
Escherichia Coli.
Synonyms
CTRP6, C1QTNF6, ZACRP6, Complement C1q tumor necrosis factor-related protein 6.
Appearance
Sterile Filtered clear solution.
Purity
Greater than 95% as determined by SDS PAGE.
Usage
THE BioTek's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
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In Stock 
Description
C1QTNF6 Human Recombinant produced in E.Coli is a single, non-glycosylated, Polypeptide chain containing 242 amino acids and having a molecular mass of 27 kDa. The protein contains an extra His tag at N-terminus. The C1QTNF6 amino acid sequence is identical to UniProtKB/Swiss-Prot entry Q9BXI9 amino acids 29–259.
The C1QTNF6 is purified by proprietary chromatographic techniques.
The C1QTNF6 is purified by proprietary chromatographic techniques.
Product Specs
Introduction
C1QTNF6, a type IV collagen, is found exclusively in basement membranes and plays a crucial role in embryonic development.
Description
Recombinant human C1QTNF6, produced in E. coli, is a non-glycosylated polypeptide chain consisting of 242 amino acids. With a molecular weight of 27 kDa, it includes an N-terminal His tag for purification. The amino acid sequence aligns with residues 29-259 of the UniProtKB/Swiss-Prot entry Q9BXI9. Purification is achieved through proprietary chromatographic techniques.
Physical Appearance
A clear, sterile-filtered solution.
Formulation
The protein is supplied at a concentration of 0.23 mg/ml in a 30 mM acetate buffer with a pH of 4.
Stability
For short-term storage (2-4 weeks), the product should be kept at 4°C. For extended storage, freeze at -20°C. Repeated freezing and thawing should be avoided.
Purity
The purity of the protein is greater than 95% as determined by SDS-PAGE analysis.
Synonyms
CTRP6, C1QTNF6, ZACRP6, Complement C1q tumor necrosis factor-related protein 6.
Source
Escherichia Coli.
Amino Acid Sequence
MKHHHHHHAS TFDRAVASGC QRCCDSEDPL DPAHVSSASS SGRPHALPEI RPYINITILK GDKGDPGPMG LPGYMGREGP QGEPGPQGSK GDKGEMGSPG APCQKRFFAF SVGRKTALHS GEDFQTLLFE RVFVNLDGCF DMATGQFAAP LRGIYFFSLN VHSWNYKETY VHIMHNQKEA VILYAQPSER SIMQSQSVML DLAYGDRVWV RLFKRQRENA IYSNDFDTYI TFSGHLIKAEDD.
Product Science Overview
Introduction
Complement C1q Tumor Necrosis Factor-Related Protein 6 (C1QTNF6) is a member of the C1q/TNF-related protein (CTRP) family. This family consists of secreted proteins that share structural similarities with the complement protein C1q and the tumor necrosis factor (TNF) superfamily. CTRPs are known for their roles in various physiological processes, including metabolism, inflammation, and immune response .
Structure
C1QTNF6, like other CTRPs, is composed of several distinct domains:
- N-terminal signal peptide: This domain is responsible for directing the protein to the secretory pathway.
- Short variable domain: This region varies among different CTRPs and contributes to their unique functions.
- Collagenous domain: This domain is characterized by a series of Gly-X-Y repeats, where X and Y are often proline and hydroxyproline, respectively. It is involved in the formation of higher-order structures.
- C-terminal globular C1q domain: This domain is homologous to the globular domain of the complement protein C1q and is crucial for the protein’s biological activity .
Function
C1QTNF6 has been implicated in various biological processes, including:
- Metabolism: C1QTNF6 plays a role in regulating glucose and lipid metabolism. It has been shown to enhance insulin sensitivity and promote fatty acid oxidation .
- Inflammation: C1QTNF6 exhibits anti-inflammatory properties by modulating the activity of immune cells and reducing the production of pro-inflammatory cytokines .
- Cellular signaling: C1QTNF6 activates several signaling pathways, including the AMP-activated protein kinase (AMPK) and AKT pathways, which are involved in maintaining cellular energy homeostasis and promoting cell survival .
Recombinant Human C1QTNF6
Research and Therapeutic Potential
C1QTNF6 has garnered significant interest in the scientific community due to its potential therapeutic applications. Studies have shown that C1QTNF6 can:
- Improve metabolic health: By enhancing insulin sensitivity and promoting lipid metabolism, C1QTNF6 may help in the management of metabolic disorders such as obesity, type 2 diabetes, and non-alcoholic fatty liver disease (NAFLD) .
- Reduce inflammation: The anti-inflammatory properties of C1QTNF6 make it a promising candidate for the treatment of inflammatory diseases, including autoimmune disorders and cardiovascular diseases .
- Support cancer therapy: Although C1QTNF6 does not directly affect tumor growth, it has been shown to reduce hypovascular tumor necrosis areas, potentially improving the efficacy of cancer treatments .
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