ANXA13 Human
Annexin A13, Annexin XIII, Annexin-13, Intestine-specific annexin, ISA, ANXA13, ANX13, MGC150460.
Description
ANXA13 Human Recombinant fused with a 20 amino acid His tag at N-terminus produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 336 amino acids (1-316 a.a.) and having a molecular mass of 37.5kDa.
The ANXA13 is purified by proprietary chromatographic techniques.
Product Specs
Annexin A13 (ANXA13) is a protein that belongs to the annexin family. Annexins are involved in various cellular processes, including interactions with the cytoskeleton, inhibition of phospholipase activity, regulation of cell growth, and intracellular signal transduction. ANXA13 is considered to be the ancestor of the 12 vertebrate annexins. Its expression is highly specific to certain tissues, primarily intestinal and kidney epithelial cells, where it plays a crucial role in a highly specialized intracellular transport mechanism.
Recombinant human ANXA13, fused with a 20 amino acid His tag at its N-terminus, is produced in E. coli. This protein is a single, non-glycosylated polypeptide chain consisting of 336 amino acids (specifically, amino acids 1 to 316) and has a molecular weight of 37.5 kDa. The purification of ANXA13 is achieved through proprietary chromatographic methods.
The ANXA13 solution is provided at a concentration of 0.5 mg/ml and contains the following components: 20 mM Tris-HCl buffer (pH 8.0), 1 mM DTT, 30% glycerol, 0.1 M NaCl, and 1 mM EDTA.
Annexin A13, Annexin XIII, Annexin-13, Intestine-specific annexin, ISA, ANXA13, ANX13, MGC150460.
MGSSHHHHHH SSGLVPRGSH MGNRHAKASS PQGFDVDRDA KKLNKACKGM GTNEAAIIEI LSGRTSDERQ QIKQKYKATY GKELEEVLKS ELSGNFEKTA LALLDRPSEY AARQLQKAMK GLGTDESVLI EVLCTRTNKE IIAIKEAYQR LFDRSLESDV KGDTSGNLKK ILVSLLQANR NEGDDVDKDL AGQDAKDLYD AGEGRWGTDE LAFNEVLAKR SYKQLRATFQ AYQILIGKDI EEAIEEETSG DLQKAYLTLV RCAQDCEDYF AERLYKSMKG AGTDEETLIR IVVTRAEVDL QGIKAKFQEK YQKSLSDMVR SDTSGDFRKL LVALLH.
Product Science Overview
Annexin A13 contains four annexin repeats, and a pair of these repeats can form one binding site for calcium and phospholipid . This structural feature is essential for its function in binding to cell membranes in a calcium-dependent manner. The protein has a calculated molecular weight of approximately 35.4 kDa, although it is observed to be around 33 kDa in experiments .
ANXA13 is highly expressed in intestinal and kidney epithelial cells . It is associated with the plasma membrane of undifferentiated, proliferating crypt epithelial cells as well as differentiated villus enterocytes . This localization suggests that ANXA13 may play a role in maintaining the integrity and function of epithelial tissues.
The specific function of ANXA13 is not yet fully determined, but its association with the plasma membrane and its expression in epithelial cells indicate its potential importance in cellular processes related to membrane dynamics and cell signaling . Recombinant human Annexin A13 is used in research to study these functions and to explore its potential role in various diseases and cellular processes.
