CD44 Anti Human

CD44 is expressed on a variety of cell types, including leukocytes, endothelial cells, hepatocytes, and mesenchymal cells . Its expression is upregulated during T cell activation and the inflammatory response . High levels of CD44 expression are characteristic of memory cell subsets and have been associated with potent suppressive functions in regulatory T cells (Tregs) through high production of IL-10 .

Research has shown that interactions between CD44 and HER2 are linked to increased ovarian carcinoma cell growth . CD44 also interacts with proteins such as ezrin, radixin, and moesin (ERM), linking the actin cytoskeleton to the plasma membrane and the ECM . These interactions are crucial for cell motility and the inflammatory response.

Mouse anti-human CD44 antibodies are monoclonal antibodies produced by immunizing mice with human leukocytes. These antibodies are used in various applications, including Western blotting, immunoprecipitation, immunohistochemistry, immunofluorescence, and flow cytometry . For example, the clone IM7 recognizes an epitope common to all isoforms of CD44 and is used in flow cytometric staining .

Mouse anti-human CD44 antibodies are valuable tools in research for studying cell adhesion, migration, and the immune response. They are used to investigate the role of CD44 in various diseases, including cancer and autoimmune disorders. These antibodies help in understanding the mechanisms of cell signaling and the interactions between cells and the ECM.