TNFRSF8 Human
Description
Product Specs
Product Science Overview
The CD30 ligand receptor, also known as TNFRSF8, is a type I transmembrane glycoprotein that belongs to the tumor necrosis factor (TNF) receptor superfamily. It is commonly referred to as CD30 and is recognized for its role in various immune responses and its association with certain types of lymphomas .
The CD30 receptor is a 120 kDa protein that consists of a 361 amino acid extracellular domain (ECD) with six cysteine-rich repeats, a 28 amino acid transmembrane segment, and a 188 amino acid cytoplasmic domain . The receptor is primarily expressed on activated T cells, B cells, and certain lymphoma cells, including Hodgkin’s and Reed-Sternberg cells .
The CD30 ligand (CD30L), also known as TNFSF8, is a type-II membrane-associated glycoprotein. It is expressed on activated T cells, monocyte-macrophages, granulocytes, eosinophils, and some Burkitt-like lymphoma cell lines . The interaction between CD30 and its ligand plays a crucial role in the regulation of immune responses, including cell proliferation, activation, differentiation, and apoptosis .
The CD30-CD30L interaction has been implicated in various biological processes. It is known to mediate pleiotropic effects, including:
- Cell Proliferation: Promotes the growth and division of certain cell types.
- Cell Activation: Activates immune cells, enhancing their response to pathogens.
- Cell Differentiation: Influences the development of immune cells into specialized types.
- Apoptosis: Induces programmed cell death in certain contexts .
The CD30 receptor and its ligand are of particular interest in the context of hematologic malignancies. CD30 is a marker for Hodgkin lymphoma and anaplastic large cell lymphoma, making it a valuable target for diagnostic and therapeutic purposes . The recombinant human CD30 ligand has been utilized in research to study its effects on various cell lines and to develop potential treatments for these malignancies .
Recombinant human CD30 ligand is produced using various expression systems, such as HEK293 cells. It is typically purified to high levels of purity and is used in research to investigate the CD30-CD30L interaction and its biological effects . The recombinant protein is often used in studies related to immune response modulation and the development of targeted therapies for CD30-positive lymphomas .
