TNFRSF10C Antibody
Tumor Necrosis Factor Receptor Superfamily, Member 10c, Decoy Without An , Intracellular Domain, TRAILR3, DCR1, TRID, TNF-Related Apoptosis-Inducing Ligand Receptor, Antagonist Decoy Receptor For TRAIL/Apo-2L, Decoy TRAIL Receptor Without Death Domain, Lymphocyte Inhibitor Of TRAIL, Decoy Receptor,TRAIL-R, LIT,Tumor Necrosis Factor Receptor Superfamily Member 10C, TRAIL Receptor Without an Intracellular Domain, Cytotoxic TRAIL Receptor, TRAIL Receptor, CD263 Antigen, DCR1-TNFR, CD263.
Description
Product Specs
Tumor Necrosis Factor Receptor Superfamily, Member 10c, Decoy Without An , Intracellular Domain, TRAILR3, DCR1, TRID, TNF-Related Apoptosis-Inducing Ligand Receptor, Antagonist Decoy Receptor For TRAIL/Apo-2L, Decoy TRAIL Receptor Without Death Domain, Lymphocyte Inhibitor Of TRAIL, Decoy Receptor,TRAIL-R, LIT,Tumor Necrosis Factor Receptor Superfamily Member 10C, TRAIL Receptor Without an Intracellular Domain, Cytotoxic TRAIL Receptor, TRAIL Receptor, CD263 Antigen, DCR1-TNFR, CD263.
TNFRSF10C antibody was purified from mouse ascitic fluids by protein-A affinity chromatography.
PAT1E12AT.
Anti-human TNFRSF10C mAb, is derived from hybridization of mouse SP2/0 myeloma cells with spleen cells from BALB/c mice immunized with Recombinant human TNFRSF10C amino acids 26-236 purified from E. coli.
Mouse IgG1 heavy chain and κ light chain.
Product Science Overview
TRAIL-R3 is a 65 kDa glycosylphosphatidylinositol (GPI)-anchored protein . Unlike other TRAIL receptors, TRAIL-R3 lacks a functional death domain, which means it cannot induce apoptosis directly. Instead, it acts as a decoy receptor by binding to the TNF-related apoptosis-inducing ligand (TRAIL), thereby inhibiting TRAIL-mediated apoptosis . This unique characteristic allows TRAIL-R3 to protect normal cells from undergoing apoptosis while allowing TRAIL to target and kill cancer cells.
TRAIL-R3 is expressed at low levels in normal tissues but is not commonly found in most tumors . Its primary role is to act as a decoy receptor, preventing TRAIL from binding to death receptors that would otherwise induce apoptosis. This protective mechanism is crucial in maintaining the balance between cell survival and death in normal tissues.
The Mouse Anti-Human TRAIL-R3 antibody is a monoclonal antibody that specifically recognizes the human TRAIL-R3 receptor. This antibody is typically used in research applications such as flow cytometry to study the expression and function of TRAIL-R3 in various cell types . The antibody is produced by immunizing mice with recombinant human TRAIL-R3/Fc protein and is purified from tissue culture supernatant or ascites by affinity chromatography .
The Mouse Anti-Human TRAIL-R3 antibody is widely used in research to investigate the role of TRAIL-R3 in apoptosis and cancer. By using this antibody, researchers can study the expression patterns of TRAIL-R3 in different cell types and tissues, understand its role in protecting normal cells from apoptosis, and explore its potential as a therapeutic target in cancer treatment .
