TNFRSF10C Human

TRAIL Receptor-3 Human Recombinant
Cat. No.
BT27405
Source
Escherichia Coli.
Synonyms
Tumor Necrosis Factor Receptor Superfamily, Member 10c, Decoy Without An , Intracellular Domain, TRAILR3, DCR1, TRID, TNF-Related Apoptosis-Inducing Ligand Receptor, Antagonist Decoy Receptor For TRAIL/Apo-2L, Decoy TRAIL Receptor Without Death Domain, Lymphocyte Inhibitor Of TRAIL, Decoy Receptor,TRAIL-R, LIT,Tumor Necrosis Factor Receptor Superfamily Member 10C, TRAIL Receptor Without an Intracellular Domain, Cytotoxic TRAIL Receptor, TRAIL Receptor, CD263 Antigen, DCR1-TNFR, CD263.
Appearance
Sterile Filtered clear solution.
Purity
Greater than 90.0% as determined by SDS-PAGE.
Usage
THE BioTek's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
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Description

TNFRSF10C Human Recombinant produced in E. coli is a single, non-glycosylated polypeptide chain containing 234 amino acids (26-236 a.a) and having a molecular mass of 24.6 kDa.
TNFRSF10C is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Product Specs

Introduction
TRAIL Receptor-3, also known as TNFRSF10C, is a member of the TNF-receptor superfamily. This receptor contains an extracellular TRAIL-binding domain and a transmembrane domain but lacks a cytoplasmic death domain. Consequently, TNFRSF10C cannot induce apoptosis. Instead, it is believed to act as an antagonistic receptor, protecting cells from apoptosis induced by TRAIL.
Description
Recombinant human TNFRSF10C, produced in E. coli, is a single, non-glycosylated polypeptide chain consisting of 234 amino acids (26-236 a.a.). It has a molecular mass of 24.6 kDa. The protein includes a 23 amino acid His-tag at the N-terminus and is purified using proprietary chromatographic techniques.
Physical Appearance
A clear, sterile-filtered solution.
Formulation
The TNFRSF10C protein solution has a concentration of 1 mg/ml and is prepared in phosphate buffered saline (pH 7.4) containing 10% glycerol.
Stability
For short-term storage (up to 2-4 weeks), the solution should be stored at 4°C. For long-term storage, it is recommended to freeze the solution at -20°C. The addition of a carrier protein like 0.1% HSA or BSA is advised for long-term storage. Avoid repeated freeze-thaw cycles.
Purity
The purity of the TNFRSF10C protein is greater than 90.0% as determined by SDS-PAGE analysis.
Synonyms
Tumor Necrosis Factor Receptor Superfamily, Member 10c, Decoy Without An , Intracellular Domain, TRAILR3, DCR1, TRID, TNF-Related Apoptosis-Inducing Ligand Receptor, Antagonist Decoy Receptor For TRAIL/Apo-2L, Decoy TRAIL Receptor Without Death Domain, Lymphocyte Inhibitor Of TRAIL, Decoy Receptor,TRAIL-R, LIT,Tumor Necrosis Factor Receptor Superfamily Member 10C, TRAIL Receptor Without an Intracellular Domain, Cytotoxic TRAIL Receptor, TRAIL Receptor, CD263 Antigen, DCR1-TNFR, CD263.
Source
Escherichia Coli.
Amino Acid Sequence
MGSSHHHHHH SSGLVPRGSH MGSATTARQE EVPQQTVAPQ QQRHSFKGEE CPAGSHRSEH TGACNPCTEG VDYTNASNNE PSCFPCTVCK SDQKHKSSCT MTRDTVCQCK EGTFRNENSP EMCRKCSRCP SGEVQVSNCT SWDDIQCVEE FGANATVETP AAEETMNTSP GTPAPAAEET MNTSPGTPAP AAEETMTTSP GTPAPAAEET MTTSPGTPAP AAEETMTTSP GTPA.

Product Science Overview

Structure and Function

TRAIL-R3 is characterized by its extracellular cysteine-rich domains that are responsible for binding TRAIL. Unlike other TRAIL receptors, TRAIL-R3 lacks an intracellular signaling domain, which means that it does not transduce an apoptosis signal upon binding to TRAIL . This unique feature classifies TRAIL-R3 as a “decoy” receptor, as it can bind to TRAIL without inducing cell death.

Role in Apoptosis

The primary function of TRAIL-R3 is to protect cells from TRAIL-induced apoptosis. By binding to TRAIL, TRAIL-R3 prevents TRAIL from interacting with other death receptors, such as TRAIL-R1 and TRAIL-R2, which do have the capability to induce apoptosis . This protective mechanism is crucial in regulating cell death and maintaining cellular homeostasis.

Expression and Clinical Relevance

TRAIL-R3 is expressed in various tissues and has been shown to play a role in immune regulation and cancer biology. Its expression can protect normal cells from TRAIL-induced apoptosis, which is beneficial in preventing unwanted cell death. However, in the context of cancer, the overexpression of TRAIL-R3 can contribute to tumor resistance to TRAIL-based therapies .

Recombinant TRAIL-R3

Recombinant human TRAIL-R3 is produced using expression systems such as HEK293 cells. The recombinant protein is often tagged with a His-tag for purification purposes and is used in research to study its structure, function, and therapeutic potential .

Research and Therapeutic Potential

Research on TRAIL-R3 has provided insights into its role in cancer therapy. By understanding how TRAIL-R3 interacts with TRAIL and other receptors, scientists aim to develop strategies to modulate its activity. For instance, targeting TRAIL-R3 to enhance TRAIL-induced apoptosis in cancer cells is a potential therapeutic approach .

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THE BIOTEK
THE BioTek is a global biotech company offering highly purified proteins for research in cancer, apoptosis, development, endocrinology, immunology, neuroscience, proteases, and stem cells.
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