TNFR2 Mouse
Description
TNFR2 Mouse Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 236 amino acids and having a molecular mass of 25.3kDa.
The TNFR2 is purified by proprietary chromatographic techniques.
Product Specs
VPAQVVLTPY KPEPGYECQI SQEYYDRKAQ MCCAKCPPGQ YVKHFCNKTS DTVCADCEAS MYTQVWNQFR TCLSCSSSCT TDQVEIRACT KQQNRVCACE AGRYCALKTH SGSCRQCMRL SKCGPGFGVA SSRAPNGNVL CKACAPGTFS DTTSSTDVCR PHRICSILAI PGNASTDAVC APESPTLSAI PRTLYVSQPE PTRSQPLDQE PGPSQTPSIL TSLGSTPIIE QSTKGG.
Product Science Overview
Tumor Necrosis Factor Receptor Type 2 (TNFR2) is a critical component in the complex network of cellular signaling, particularly in the context of immune responses and tumor biology. This receptor, along with its counterpart TNFR1, mediates the effects of Tumor Necrosis Factor (TNF), a cytokine involved in inflammation, apoptosis, and cell proliferation.
TNFR2 is a member of the TNF receptor superfamily and is primarily expressed on immune cells, including regulatory T cells (Tregs) and myeloid-derived suppressor cells (MDSCs). Unlike TNFR1, which is ubiquitously expressed, TNFR2 has a more restricted expression pattern, which allows it to play specialized roles in immune regulation and tumor progression .
Recombinant mouse TNFR2 is a laboratory-engineered version of the receptor, designed to mimic the natural receptor’s structure and function. This recombinant protein is used extensively in research to study the receptor’s role in various biological processes and disease models. By using recombinant TNFR2, scientists can investigate the receptor’s signaling pathways, interactions with ligands, and potential as a therapeutic target .
TNFR2 is known to activate several signaling pathways that contribute to immune regulation. One of the key pathways involves the recruitment of TNF receptor-associated factors (TRAFs), which subsequently activate nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) and other transcription factors. These signaling events lead to the expression of genes involved in cell survival, proliferation, and differentiation .
In the context of immune regulation, TNFR2 plays a pivotal role in the expansion and function of Tregs. These cells are crucial for maintaining immune tolerance and preventing autoimmune responses. TNFR2-mediated signaling enhances the survival and suppressive function of Tregs, thereby contributing to immune homeostasis .
TNFR2 is also implicated in tumor biology, particularly in the tumor microenvironment. The receptor is expressed on various tumor cells and immune cells within the tumor microenvironment, where it promotes tumor growth and immune evasion. TNFR2 signaling can enhance the proliferation of tumor cells and support the immunosuppressive functions of Tregs and MDSCs, creating a more favorable environment for tumor progression .
Given its significant roles in immune regulation and tumor biology, TNFR2 is considered a promising therapeutic target. Strategies to modulate TNFR2 activity include the use of agonists to enhance its beneficial effects in immune regulation or antagonists to inhibit its pro-tumor functions. Ongoing research aims to develop targeted therapies that can selectively modulate TNFR2 signaling to treat various diseases, including cancer and autoimmune disorders .
