TBEV gE middle
Sterile Filtered clear solution.
Description
Product Specs
Product Science Overview
Tick-Borne Encephalitis Virus (TBEV) is a significant pathogen within the Flaviviridae family, responsible for causing tick-borne encephalitis (TBE), a severe neurological disease. TBEV is primarily transmitted through the bite of infected ticks, particularly Ixodes ricinus and Ixodes persulcatus. The virus is endemic in various regions, including Central and Eastern Europe, Russia, and parts of Asia .
TBEV is a positive-sense, single-stranded RNA virus. The viral genome encodes three structural proteins: the capsid ©, membrane (M), and envelope (E) proteins. The envelope (E) protein is particularly crucial as it mediates viral entry into host cells and is the primary target for neutralizing antibodies .
The gE Middle recombinant protein refers to a specific segment of the TBEV envelope (E) protein. This recombinant protein is engineered to include the middle portion of the E protein, which is essential for the virus’s ability to infect host cells and elicit an immune response. The recombinant gE Middle protein is often used in research and vaccine development to study the virus’s pathogenic mechanisms and to develop effective vaccines .
The gE Middle recombinant protein plays a pivotal role in vaccine development against TBEV. By focusing on this segment of the E protein, researchers aim to create vaccines that can induce a robust immune response, providing protection against the virus. The recombinant protein is used to evaluate the efficacy of potential vaccines and to understand the immune mechanisms involved in protection .
Studies have shown that the envelope protein of TBEV, including the gE Middle segment, significantly influences the virus’s ability to enter neurons, its pathogenicity, and the effectiveness of vaccines. For instance, specific amino acid substitutions in the E protein can enhance the virus’s neurovirulence and replication in vivo . These findings underscore the importance of the gE Middle recombinant protein in understanding TBEV’s behavior and developing effective countermeasures.
