TBEV gE C-end
Description
Product Specs
Product Science Overview
Tick-Borne Encephalitis Virus (TBEV) is a positive-sense, single-stranded RNA virus belonging to the family Flaviviridae and the genus Flavivirus . It is considered one of the most medically significant arthropod-borne viruses in Europe, causing a range of symptoms from subclinical to severe encephalitis . The virus is primarily transmitted through tick bites and, less commonly, through the consumption of unpasteurized dairy products from infected animals .
The envelope (E) protein of TBEV plays a crucial role in the virus’s ability to infect host cells. It is located on the surface of the viral particle and is responsible for mediating the fusion of the viral membrane with the host cell membrane . The E protein is also the major target for neutralizing antibodies, making it a key component in vaccine development .
The gE C-end refers to the C-terminal end of the E protein. Recombinant versions of this protein segment have been developed to study its role in the virus’s pathogenicity and to explore its potential in vaccine formulations . Recombinant proteins are produced by inserting the gene encoding the protein into a host cell, such as E. coli, which then expresses the protein. This allows for the production of large quantities of the protein for research and vaccine development .
Research has shown that the E protein, including its C-terminal end, is a significant determinant of the virus’s ability to infect neurons and cause disease . For instance, specific amino acid substitutions in the E protein have been linked to increased neurovirulence and pathogenicity . These findings are crucial for understanding the mechanisms of TBEV infection and for developing effective vaccines.
Recombinant versions of the E protein, including the gE C-end, have been used in various studies to evaluate their immunogenicity and protective efficacy . For example, recombinant domains of the E protein have been shown to induce immune responses and provide partial protection against TBEV infection in animal models . These studies highlight the potential of recombinant E protein segments in the development of subunit vaccines and diagnostic tools.
