TBEV Core
Description
Product Specs
Product Science Overview
Tick-borne encephalitis virus (TBEV) is a significant pathogen within the Flaviviridae family, which also includes other notable viruses such as Zika, dengue, West Nile, and Japanese encephalitis viruses . TBEV is a positive-sense, single-stranded RNA virus that primarily affects the central nervous system, leading to a range of symptoms from mild flu-like illness to severe neurological complications, including encephalitis .
The core protein of TBEV plays a crucial role in the virus’s life cycle. It is involved in the encapsidation of the viral RNA genome, forming the nucleocapsid, which is essential for the protection and delivery of the viral genome into host cells. The core protein also interacts with other viral and host proteins to facilitate viral replication and assembly.
Recombinant proteins are produced through recombinant DNA technology, which involves inserting the gene encoding the protein of interest into an expression system, such as bacteria, yeast, or mammalian cells. The recombinant TBEV core protein is produced by expressing the TBEV core protein gene in a suitable host system, allowing for the production of large quantities of the protein for research and diagnostic purposes.
- Vaccine Development: The recombinant core protein can be used as an antigen in vaccine formulations to elicit an immune response against TBEV. This approach is being explored to develop safer and more effective vaccines against tick-borne encephalitis.
- Diagnostic Tools: Recombinant TBEV core protein can be used in serological assays to detect antibodies against TBEV in patient samples. This is crucial for the accurate diagnosis of tick-borne encephalitis, especially in endemic regions.
- Research: The recombinant core protein is valuable for studying the molecular mechanisms of TBEV infection and pathogenesis. It allows researchers to investigate the interactions between the core protein and other viral or host proteins, providing insights into the virus’s life cycle and potential therapeutic targets.
