STMN3 Human
Description
Product Specs
Product Science Overview
Stathmin proteins, including STMN3, interact with tubulin, the building block of microtubules. They form a complex with tubulins at a ratio of 2 tubulins for each stathmin protein . This interaction disrupts the assembly of microtubules, thereby regulating their formation and function. The ability to modulate microtubule dynamics is vital for various cellular processes, including mitosis and cell motility.
STMN3 is expressed in various tissues, with higher expression levels observed in the brain. This suggests a potential role in neuronal development and function. The protein is localized in the cytoplasm, where it can readily interact with tubulin to influence microtubule dynamics.
Recombinant human STMN3 is produced using genetic engineering techniques, where the STMN3 gene is cloned and expressed in suitable host cells, such as E. coli or mammalian cells. The recombinant protein is then purified for research and therapeutic applications. It is typically supplied in a solution containing buffers like Tris-HCl, DTT, and glycerol to maintain its stability .
Recombinant STMN3 is used in various research applications, including:
- Studying microtubule dynamics: Researchers use STMN3 to investigate how microtubule assembly and disassembly are regulated.
- Neurobiology: Given its high expression in the brain, STMN3 is studied for its role in neuronal development and function.
- Cancer research: Abnormal regulation of microtubules is a hallmark of cancer. STMN3 is explored for its potential role in cancer progression and as a therapeutic target.
